A phosphorescent rhenium(I) tricarbonyl polypyridine complex appended with a fructose pendant that exhibits photocytotoxicity and enhanced uptake by breast cancer cells

Kenneth Yin Zhang; Karson Ka-Shun Tso; Man-Wai Louie; Hua-Wei Liu; Kenneth Kam-Wing Lo

doi:10.1021/om400612f

A phosphorescent rhenium(I) tricarbonyl polypyridine complex appended with a fructose pendant that exhibits photocytotoxicity and enhanced uptake by breast cancer cells

Kenneth Yin Zhang
, Karson Ka-Shun Tso
, Man-Wai Louie
, Hua-Wei Liu
, Kenneth Kam-Wing Lo

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

78 Citations (Scopus)

Abstract

We demonstrated that the cytotoxicity of a phosphorescent rhenium(I) polypyridine complex with a fructose pendant was enhanced upon irradiation and the cellular uptake of the complex was mediated by fructose transporters and inhibited by unmodified fructose but was independent of glucose-specific transporters. This complex has been used to image breast cancer cells, where fructose transporters are overexpressed. © 2013 American Chemical Society.

Original language	English
Pages (from-to)	5098-5102
Journal	Organometallics
Volume	32
Issue number	18
DOIs	https://doi.org/10.1021/om400612f
Publication status	Published - 23 Sept 2013

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title = "A phosphorescent rhenium(I) tricarbonyl polypyridine complex appended with a fructose pendant that exhibits photocytotoxicity and enhanced uptake by breast cancer cells",

abstract = "We demonstrated that the cytotoxicity of a phosphorescent rhenium(I) polypyridine complex with a fructose pendant was enhanced upon irradiation and the cellular uptake of the complex was mediated by fructose transporters and inhibited by unmodified fructose but was independent of glucose-specific transporters. This complex has been used to image breast cancer cells, where fructose transporters are overexpressed. {\textcopyright} 2013 American Chemical Society.",

author = "\{Yin Zhang\}, Kenneth and \{Ka-Shun Tso\}, Karson and Man-Wai Louie and Hua-Wei Liu and \{Kam-Wing Lo\}, Kenneth",

year = "2013",

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day = "23",

doi = "10.1021/om400612f",

language = "English",

volume = "32",

pages = "5098--5102",

journal = "Organometallics",

issn = "0276-7333",

publisher = "American Chemical Society",

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A phosphorescent rhenium(I) tricarbonyl polypyridine complex appended with a fructose pendant that exhibits photocytotoxicity and enhanced uptake by breast cancer cells. / Yin Zhang, Kenneth; Ka-Shun Tso, Karson; Louie, Man-Wai et al.
In: Organometallics, Vol. 32, No. 18, 23.09.2013, p. 5098-5102.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

TY - JOUR

T1 - A phosphorescent rhenium(I) tricarbonyl polypyridine complex appended with a fructose pendant that exhibits photocytotoxicity and enhanced uptake by breast cancer cells

AU - Yin Zhang, Kenneth

AU - Ka-Shun Tso, Karson

AU - Louie, Man-Wai

AU - Liu, Hua-Wei

AU - Kam-Wing Lo, Kenneth

PY - 2013/9/23

Y1 - 2013/9/23

N2 - We demonstrated that the cytotoxicity of a phosphorescent rhenium(I) polypyridine complex with a fructose pendant was enhanced upon irradiation and the cellular uptake of the complex was mediated by fructose transporters and inhibited by unmodified fructose but was independent of glucose-specific transporters. This complex has been used to image breast cancer cells, where fructose transporters are overexpressed. © 2013 American Chemical Society.

AB - We demonstrated that the cytotoxicity of a phosphorescent rhenium(I) polypyridine complex with a fructose pendant was enhanced upon irradiation and the cellular uptake of the complex was mediated by fructose transporters and inhibited by unmodified fructose but was independent of glucose-specific transporters. This complex has been used to image breast cancer cells, where fructose transporters are overexpressed. © 2013 American Chemical Society.

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UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-84884604738&origin=recordpage

U2 - 10.1021/om400612f

DO - 10.1021/om400612f

M3 - RGC 21 - Publication in refereed journal

SN - 0276-7333

VL - 32

SP - 5098

EP - 5102

JO - Organometallics

JF - Organometallics

IS - 18

ER -

A phosphorescent rhenium(I) tricarbonyl polypyridine complex appended with a fructose pendant that exhibits photocytotoxicity and enhanced uptake by breast cancer cells

Abstract

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