A Phosphorescent Rhenium(I) Polypyridine Fructose Complex That Exhibits Selective Uptake by Breast Cancer Cells and Photocytotoxicity

Karson Ka-Shun Tso; Kenneth Yin Zhang; Man-Wai Louie; Hua-Wei Liu; Kenneth Kam-Wing Lo

A Phosphorescent Rhenium(I) Polypyridine Fructose Complex That Exhibits Selective Uptake by Breast Cancer Cells and Photocytotoxicity

Karson Ka-Shun Tso
, Kenneth Yin Zhang
, Man-Wai Louie
, Hua-Wei Liu
, Kenneth Kam-Wing Lo

Research output: Conference Papers › RGC 33 - Other conference paper

Abstract

We have synthesized and characterized a phosphorescent rhenium(I) polypyridine fructose complex [Re(Ph₂-phen)(CO)₃(py-fructose)](CF₃SO₃) and studied its photophysical and biological properties. On the basis of competitive experiments involving unmodified fructose, the cellular uptake of the complex was found to be mediated by membrane-bound fructose transporters. As such, the complex was selectively internalized by breast cancer cell lines including MCF-7 and MDA-MB241, which overexpress fructose transporters. Additionally, the complex exhibited significantly increased cytotoxicity upon photoirradiation. Various experiments have revealed that this enhanced cytotoxic potency was due to singlet oxygen generation by the excited complex.

Original language	English
Publication status	Presented - 14 Jan 2015
Event	1st BCH Students' Conference - City University of Hong Kong, Hong Kong, China Duration: 14 Jan 2015 → 14 Jan 2015 http://www.cityu.edu.hk/chem/bchstdconf/index.html http://www.cityu.edu.hk/chem/bchstdconf/download/The%201st%20BCH%20Students'%20Conference%20-%20Booklet%20(Final).pdf

Conference

Conference	1st BCH Students' Conference
Place	Hong Kong, China
Period	14/01/15 → 14/01/15
Internet address	http://www.cityu.edu.hk/chem/bchstdconf/index.html http://www.cityu.edu.hk/chem/bchstdconf/download/The%201st%20BCH%20Students'%20Conference%20-%20Booklet%20(Final).pdf

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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@conference{32d75e659a4445ddb521bcf50537059b,

title = "A Phosphorescent Rhenium(I) Polypyridine Fructose Complex That Exhibits Selective Uptake by Breast Cancer Cells and Photocytotoxicity",

abstract = "We have synthesized and characterized a phosphorescent rhenium(I) polypyridine fructose complex [Re(Ph2-phen)(CO)3(py-fructose)](CF3SO3) and studied its photophysical and biological properties. On the basis of competitive experiments involving unmodified fructose, the cellular uptake of the complex was found to be mediated by membrane-bound fructose transporters. As such, the complex was selectively internalized by breast cancer cell lines including MCF-7 and MDA-MB241, which overexpress fructose transporters. Additionally, the complex exhibited significantly increased cytotoxicity upon photoirradiation. Various experiments have revealed that this enhanced cytotoxic potency was due to singlet oxygen generation by the excited complex. ",

author = "Tso, \{Karson Ka-Shun\} and Zhang, \{Kenneth Yin\} and Man-Wai Louie and Hua-Wei Liu and Lo, \{Kenneth Kam-Wing\}",

year = "2015",

month = jan,

day = "14",

language = "English",

note = "1st BCH Students' Conference ; Conference date: 14-01-2015 Through 14-01-2015",

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TY - CONF

T1 - A Phosphorescent Rhenium(I) Polypyridine Fructose Complex That Exhibits Selective Uptake by Breast Cancer Cells and Photocytotoxicity

AU - Tso, Karson Ka-Shun

AU - Zhang, Kenneth Yin

AU - Louie, Man-Wai

AU - Liu, Hua-Wei

AU - Lo, Kenneth Kam-Wing

PY - 2015/1/14

Y1 - 2015/1/14

N2 - We have synthesized and characterized a phosphorescent rhenium(I) polypyridine fructose complex [Re(Ph2-phen)(CO)3(py-fructose)](CF3SO3) and studied its photophysical and biological properties. On the basis of competitive experiments involving unmodified fructose, the cellular uptake of the complex was found to be mediated by membrane-bound fructose transporters. As such, the complex was selectively internalized by breast cancer cell lines including MCF-7 and MDA-MB241, which overexpress fructose transporters. Additionally, the complex exhibited significantly increased cytotoxicity upon photoirradiation. Various experiments have revealed that this enhanced cytotoxic potency was due to singlet oxygen generation by the excited complex.

AB - We have synthesized and characterized a phosphorescent rhenium(I) polypyridine fructose complex [Re(Ph2-phen)(CO)3(py-fructose)](CF3SO3) and studied its photophysical and biological properties. On the basis of competitive experiments involving unmodified fructose, the cellular uptake of the complex was found to be mediated by membrane-bound fructose transporters. As such, the complex was selectively internalized by breast cancer cell lines including MCF-7 and MDA-MB241, which overexpress fructose transporters. Additionally, the complex exhibited significantly increased cytotoxicity upon photoirradiation. Various experiments have revealed that this enhanced cytotoxic potency was due to singlet oxygen generation by the excited complex.

M3 - RGC 33 - Other conference paper

T2 - 1st BCH Students' Conference

Y2 - 14 January 2015 through 14 January 2015

ER -

A Phosphorescent Rhenium(I) Polypyridine Fructose Complex That Exhibits Selective Uptake by Breast Cancer Cells and Photocytotoxicity

Abstract

Conference

UN SDGs

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