A novel ratiometric two-photon fluorescent probe for imaging of Pd2 + ions in living cells and tissues

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

16 Scopus Citations
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Author(s)

  • Liyi Zhou
  • Shunqin Hu
  • Haifei Wang
  • Hongyan Sun
  • Xiaobing Zhang

Detail(s)

Original languageEnglish
Pages (from-to)25-30
Journal / PublicationSpectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Volume166
Online published12 May 2016
Publication statusPublished - 5 Sep 2016

Abstract

Ratiometric two-photon fluorescent probes can not only eliminate interferences from environmental factors but also achieve deep-tissue imaging with improved spatial localization. To quantitatively track Pd2 + in biosystems, herein, we reported a ratiometric two-photon fluorescent probe, termed as Np-Pd, which based on a D-π-A-structure two-photon fluorophore of the naphthalimide derivative and deprotection of aryl propargyl ethers by palladium species. The probe Np-Pd displayed a more than 25-fold enhancement towards palladium species with high sensitivity and selectivity. Additionally, the probe Np-Pd was further used for fluorescence imaging of Pd2 + ions in living cells and tissues under two-photon excitation (820 nm), which showed large tissue-imaging depth (19.6-184.6 μm), and a high resolution for ratiometric imaging.

Research Area(s)

  • Fluorescent imaging, Naphthalimide derivative, Palladium, Ratiometric fluorescent probe, Two-photon

Citation Format(s)

A novel ratiometric two-photon fluorescent probe for imaging of Pd2 + ions in living cells and tissues. / Zhou, Liyi; Hu, Shunqin; Wang, Haifei; Sun, Hongyan; Zhang, Xiaobing.

In: Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, Vol. 166, 05.09.2016, p. 25-30.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal