A novel miR-193a-5p-YY1-APC regulatory axis in human endometrioid endometrial adenocarcinoma

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Y. Yang
  • L. Zhou
  • L. Lu
  • L. Wang
  • X. Li
  • P. Jiang
  • L. K.Y. Chan
  • T. Zhang
  • J. Yu
  • J. Kwong
  • T. H. Cheung
  • T. Chung
  • H. Sun
  • H. Wang

Detail(s)

Original languageEnglish
Pages (from-to)3432-3442
Journal / PublicationOncogene
Volume32
Issue number29
Publication statusPublished - 18 Jul 2013
Externally publishedYes

Abstract

Aberrant expression and altered function of transcription factors (TFs) have vital roles in many aspects of tumor development and progression. In this study, we investigated the functional significance of a TF, Yin Yang1 (YY1) in tumorigenesis of endometrioid endometrial carcinoma (EEC). We demonstrated that YY1 is upregulated in EEC cell lines and primary tumors; and its expression is associated with tumor stages. Depletion of YY1 inhibits EEC cell proliferation and migration both in vitro and in vivo, whereas overexpression of YY1 promotes EEC cell growth. These results suggest that YY1 functions as an oncogenic factor in EEC. Transcriptome analysis revealed a significant effect of YY1 on critical aspects of EEC tumorigenesis through inhibition of APC expression. Further mechanistic investigation uncovered a new epigenetic silencing mode of APC by YY1 through recruitment of EZH2 and trimethylation of histone 3 lysine 27 on its promoter region. Moreover, YY1 overexpression was found to be a consequence of miR-193a-5p downregulation through direct miR-193a-5p-YY1 interplay. Our results therefore establish a novel miR-193a-5p-YY1-APC axis, which contributes to EEC development, and may serve as future intervention target. © 2013 Macmillan Publishers Limited All rights reserved.

Research Area(s)

  • APC, EEC, EZH2, H3K27me3, MicroRNA, YY1

Bibliographic Note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to lbscholars@cityu.edu.hk.

Citation Format(s)

A novel miR-193a-5p-YY1-APC regulatory axis in human endometrioid endometrial adenocarcinoma. / Yang, Y.; Zhou, L.; Lu, L. et al.
In: Oncogene, Vol. 32, No. 29, 18.07.2013, p. 3432-3442.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review