A Novel Double-Crosslinking-Double-Network Design for Injectable Hydrogels with Enhanced Tissue Adhesion and Antibacterial Capability for Wound Treatment

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

13 Scopus Citations
View graph of relations

Author(s)

  • Lei Wang
  • Xuehui Zhang
  • Kun Yang
  • Yu Vincent Fu
  • Tianshun Xu
  • Shengliang Li
  • Dawei Zhang
  • Lu-Ning Wang

Detail(s)

Original languageEnglish
Article number1904156
Journal / PublicationAdvanced Functional Materials
Publication statusOnline published - 11 Nov 2019

Abstract

Most photocrosslinkable hydrogels have inadequacy in either mechanical performance or biodegradability. This issue is addressed by adopting a novel hydrogel design by introducing two different chitosan chains (catechol-modified methacryloyl chitosan, CMC; methacryloyl chitosan, MC) via the simultaneous crosslinking of carbon-carbon double bonds and catechol-Fe3+ chelation. This leads to an interpenetrating network of two chitosan chains with high crosslinking-network density, which enhances mechanical performance including high compressive modulus and high ductility. The chitosan polymers not only endow the hydrogels with good biodegradability and biocompatibility, they also offer intrinsic antibacterial capability. The quinone groups formed by Fe3+ oxidation and protonated amino groups of chitosan polymer further enhance antibacterial property of the hydrogels. Serving as one of the two types of crosslinking mechanisms, the catechol-Fe3+ chelation can covalently link with amino, thiol, and imidazole groups, which substantially enhance the hydrogel's adhesion to biological tissues. The hydrogel's adhesion to porcine skin shows a lap shear strength of 18.1 kPa, which is 6-time that of the clinically established Fibrin Glue's adhesion. The hydrogel also has a good hemostatic performance due to the superior tissue adhesion as demonstrated with a hemorrhaging liver model. Furthermore, the hydrogel can remarkably promote healing of bacteria-infected wound.

Research Area(s)

  • antibacterial capability, double-crosslinking-double-network, photocrosslinkable and injectable chitosan, tissue adhesion, wound healing, ACID-BASED HYDROGELS, ANTIMICROBIAL PROPERTIES, BIOMEDICAL APPLICATIONS, CHITOSAN, DEGRADATION, CHEMISTRY, HEMOSTASIS, POLYMERS, PROVIDE

Citation Format(s)

A Novel Double-Crosslinking-Double-Network Design for Injectable Hydrogels with Enhanced Tissue Adhesion and Antibacterial Capability for Wound Treatment. / Wang, Lei; Zhang, Xuehui; Yang, Kun; Fu, Yu Vincent; Xu, Tianshun; Li, Shengliang; Zhang, Dawei; Wang, Lu-Ning; Lee, Chun-Sing.

In: Advanced Functional Materials, 11.11.2019.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal