A novel distyryl boron dipyrromethene with two functional tags for site-specific bioorthogonal photosensitisation towards targeted photodynamic therapy
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Author(s)
Related Research Unit(s)
Detail(s)
Original language | English |
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Pages (from-to) | 13518-13521 |
Journal / Publication | Chemical Communications |
Volume | 55 |
Issue number | 90 |
Online published | 5 Oct 2019 |
Publication status | Published - 21 Nov 2019 |
Link(s)
Abstract
A distyryl boron dipyrromethene based photosensitiser substituted with 1,2,4,5-tetrazine and alkyne moieties was prepared. Through site-specific bioorthogonal reactions with the complementary functional tags anchored on themembrane of A431 human epidermoid carcinoma cells, this versatile photosensitiser exhibited enhanced cellular uptake and photocytotoxicity. The bioorthogonal ligation was also demonstrated in tumour-bearing nude mice.
Research Area(s)
- Bioorthogonal chemistry, PDT
Bibliographic Note
Information for this record is supplemented by the author(s) concerned.
Citation Format(s)
A novel distyryl boron dipyrromethene with two functional tags for site-specific bioorthogonal photosensitisation towards targeted photodynamic therapy. / Guo, Xuejiao; Wong, Roy C. H.; Zhou, Yimin et al.
In: Chemical Communications, Vol. 55, No. 90, 21.11.2019, p. 13518-13521.
In: Chemical Communications, Vol. 55, No. 90, 21.11.2019, p. 13518-13521.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review