A novel distyryl boron dipyrromethene with two functional tags for site-specific bioorthogonal photosensitisation towards targeted photodynamic therapy

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

19 Scopus Citations
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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)13518-13521
Journal / PublicationChemical Communications
Volume55
Issue number90
Online published5 Oct 2019
Publication statusPublished - 21 Nov 2019

Abstract

A distyryl boron dipyrromethene based photosensitiser substituted with 1,2,4,5-tetrazine and alkyne moieties was prepared. Through site-specific bioorthogonal reactions with the complementary functional tags anchored on themembrane of A431 human epidermoid carcinoma cells, this versatile photosensitiser exhibited enhanced cellular uptake and photocytotoxicity. The bioorthogonal ligation was also demonstrated in tumour-bearing nude mice.

Research Area(s)

  • Bioorthogonal chemistry, PDT

Bibliographic Note

Information for this record is supplemented by the author(s) concerned.

Citation Format(s)

A novel distyryl boron dipyrromethene with two functional tags for site-specific bioorthogonal photosensitisation towards targeted photodynamic therapy. / Guo, Xuejiao; Wong, Roy C. H.; Zhou, Yimin et al.
In: Chemical Communications, Vol. 55, No. 90, 21.11.2019, p. 13518-13521.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review