A NIR molecular rotor photosensitizer for efficient PDT and synchronous mitochondrial viscosity imaging

Liu Yang; Qingxin Chen; Yingpeng Wan; Shenglong Gan; Shengliang Li; Chun-Sing Lee; Yin Jiang; Huatang Zhang; Hongyan Sun

doi:10.1039/d2cc03592h

A NIR molecular rotor photosensitizer for efficient PDT and synchronous mitochondrial viscosity imaging

Liu Yang^*, Qingxin Chen, Yingpeng Wan, Shenglong Gan, Shengliang Li, Chun-Sing Lee, Yin Jiang, Huatang Zhang^*, Hongyan Sun^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

20 Citations (Scopus)

Abstract

Herein, two mitochondria-targeting photosensitizers (PSs, CCVJ-Mito-1 and CCVJ-Mito-2) that exhibit a turn-on fluorescence response towards increasing viscosity are reported. Notably, CCVJ-Mito-2 exhibits absorption in the near-infrared (NIR) region, and can be employed as a NIR PS targeting mitochondria and a fluorescent probe for tracking mitochondrial viscosity changes during photodynamic therapy (PDT). This dual functional PS can help to shed light on the dynamic changes of the cellular microenvironment during PDT and further guide the PDT process. © The Royal Society of Chemistry 2022.

Original language	English
Pages (from-to)	9425-9428
Journal	Chemical Communications
Volume	58
Issue number	67
Online published	25 Jul 2022
DOIs	https://doi.org/10.1039/d2cc03592h
Publication status	Published - 28 Aug 2022

Funding

This work was supported by the National Natural Science Foundation of China (32122003, 22078067), the Research Grants Council of Hong Kong (11102719 and 11302320), the Science Technology and Innovation Committee of Shenzhen Municipality (JCYJ20180507181654823), and the Guangdong Basic and Applied Basic Research Foundation (2020A1515011463).

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@article{67e1ace947184f0fbdf0f9069057814a,

title = "A NIR molecular rotor photosensitizer for efficient PDT and synchronous mitochondrial viscosity imaging",

abstract = "Herein, two mitochondria-targeting photosensitizers (PSs, CCVJ-Mito-1 and CCVJ-Mito-2) that exhibit a turn-on fluorescence response towards increasing viscosity are reported. Notably, CCVJ-Mito-2 exhibits absorption in the near-infrared (NIR) region, and can be employed as a NIR PS targeting mitochondria and a fluorescent probe for tracking mitochondrial viscosity changes during photodynamic therapy (PDT). This dual functional PS can help to shed light on the dynamic changes of the cellular microenvironment during PDT and further guide the PDT process. {\textcopyright} The Royal Society of Chemistry 2022.",

author = "Liu Yang and Qingxin Chen and Yingpeng Wan and Shenglong Gan and Shengliang Li and Chun-Sing Lee and Yin Jiang and Huatang Zhang and Hongyan Sun",

year = "2022",

month = aug,

day = "28",

doi = "10.1039/d2cc03592h",

language = "English",

volume = "58",

pages = "9425--9428",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "67",

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TY - JOUR

T1 - A NIR molecular rotor photosensitizer for efficient PDT and synchronous mitochondrial viscosity imaging

AU - Yang, Liu

AU - Chen, Qingxin

AU - Wan, Yingpeng

AU - Gan, Shenglong

AU - Li, Shengliang

AU - Lee, Chun-Sing

AU - Jiang, Yin

AU - Zhang, Huatang

AU - Sun, Hongyan

PY - 2022/8/28

Y1 - 2022/8/28

N2 - Herein, two mitochondria-targeting photosensitizers (PSs, CCVJ-Mito-1 and CCVJ-Mito-2) that exhibit a turn-on fluorescence response towards increasing viscosity are reported. Notably, CCVJ-Mito-2 exhibits absorption in the near-infrared (NIR) region, and can be employed as a NIR PS targeting mitochondria and a fluorescent probe for tracking mitochondrial viscosity changes during photodynamic therapy (PDT). This dual functional PS can help to shed light on the dynamic changes of the cellular microenvironment during PDT and further guide the PDT process. © The Royal Society of Chemistry 2022.

AB - Herein, two mitochondria-targeting photosensitizers (PSs, CCVJ-Mito-1 and CCVJ-Mito-2) that exhibit a turn-on fluorescence response towards increasing viscosity are reported. Notably, CCVJ-Mito-2 exhibits absorption in the near-infrared (NIR) region, and can be employed as a NIR PS targeting mitochondria and a fluorescent probe for tracking mitochondrial viscosity changes during photodynamic therapy (PDT). This dual functional PS can help to shed light on the dynamic changes of the cellular microenvironment during PDT and further guide the PDT process. © The Royal Society of Chemistry 2022.

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UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85135566442&origin=recordpage

U2 - 10.1039/d2cc03592h

DO - 10.1039/d2cc03592h

M3 - RGC 21 - Publication in refereed journal

C2 - 35916476

SN - 1359-7345

VL - 58

SP - 9425

EP - 9428

JO - Chemical Communications

JF - Chemical Communications

IS - 67

ER -

A NIR molecular rotor photosensitizer for efficient PDT and synchronous mitochondrial viscosity imaging

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GRF: Developing Isoxazoles as Novel Photo-cross-linkers and Its Application in Chemical Proteomics

GRF: Peptide Self-assembly Tools for Detecting Sirt5 Activity in Living Cells

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A NIR molecular rotor photosensitizer for efficient PDT and synchronous mitochondrial viscosity imaging

Abstract

Funding

RGC Funding Information

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GRF: Developing Isoxazoles as Novel Photo-cross-linkers and Its Application in Chemical Proteomics

GRF: Peptide Self-assembly Tools for Detecting Sirt5 Activity in Living Cells

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