A new method of screening human papillomavirus genotypes and clinical validation

Peng-Jun Zhang; Xin-Xin Deng; Gan-Rong Bai; Shu-Fang Jiang; Cui-Lian Lu; Xue-Ji Zhang; Hong-Li Tong; Ye-Nong Du; Hua-Yang Fu; Peng Huang; Ying Ma; Ya-Ping Tian

A new method of screening human papillomavirus genotypes and clinical validation

Peng-Jun Zhang, Xin-Xin Deng, Gan-Rong Bai, Shu-Fang Jiang, Cui-Lian Lu, Xue-Ji Zhang, Hong-Li Tong, Ye-Nong Du, Hua-Yang Fu, Peng Huang, Ying Ma, Ya-Ping Tian

City University of Hong Kong

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

1 Citation (Scopus)

Abstract

Human papillomavirus (HPV) infection is a necessary factor in the development of cervical cancer. A new HPV screening method, "Human Papillomavirus Genotyping (HPG)", was developed to detect 29 HPV genotypes distribution in China. The utility of HPG was compared to Hybrid Capture 2 High-Risk HPV DNA test (HC2), and it was determined that the HPG test had been proven to be a more credible and sensitive screening HPV method than the HC2 test. HPV16, HPV 52, HPV 56, and HPV 58 were the four most common HPV genotypes in women who have suffered chronic cervicitis or abnormal vaginal bleeding in China. HPV 16 (28.57%) and 18 (17.86%) were more likely to infect multiple HPV genotypes than other HPV genotypes. Age group more than 50 years had a higher risk than other age groups.

Original language	English
Pages (from-to)	1015-1027
Journal	Frontiers in Bioscience - Elite
Volume	2 E
Issue number	3
Publication status	Published - 1 Jun 2010

Bibliographical note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Funding

This study was supported by the Ministry of Science and Technology of China (2006FY230300,) and the Shenzhen Ganglong Biotech Company to provide the reagents for this research program.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

Genotype
Human papillomavirus
Human Papillomavirus Genotyping
Hybrid Capture 2 High-Risk HPV DNA test

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AU - Lu, Cui-Lian

AU - Zhang, Xue-Ji

AU - Tong, Hong-Li

AU - Du, Ye-Nong

AU - Fu, Hua-Yang

AU - Huang, Peng

AU - Ma, Ying

AU - Tian, Ya-Ping

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N2 - Human papillomavirus (HPV) infection is a necessary factor in the development of cervical cancer. A new HPV screening method, "Human Papillomavirus Genotyping (HPG)", was developed to detect 29 HPV genotypes distribution in China. The utility of HPG was compared to Hybrid Capture 2 High-Risk HPV DNA test (HC2), and it was determined that the HPG test had been proven to be a more credible and sensitive screening HPV method than the HC2 test. HPV16, HPV 52, HPV 56, and HPV 58 were the four most common HPV genotypes in women who have suffered chronic cervicitis or abnormal vaginal bleeding in China. HPV 16 (28.57%) and 18 (17.86%) were more likely to infect multiple HPV genotypes than other HPV genotypes. Age group more than 50 years had a higher risk than other age groups.

AB - Human papillomavirus (HPV) infection is a necessary factor in the development of cervical cancer. A new HPV screening method, "Human Papillomavirus Genotyping (HPG)", was developed to detect 29 HPV genotypes distribution in China. The utility of HPG was compared to Hybrid Capture 2 High-Risk HPV DNA test (HC2), and it was determined that the HPG test had been proven to be a more credible and sensitive screening HPV method than the HC2 test. HPV16, HPV 52, HPV 56, and HPV 58 were the four most common HPV genotypes in women who have suffered chronic cervicitis or abnormal vaginal bleeding in China. HPV 16 (28.57%) and 18 (17.86%) were more likely to infect multiple HPV genotypes than other HPV genotypes. Age group more than 50 years had a higher risk than other age groups.

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KW - Human Papillomavirus Genotyping

KW - Hybrid Capture 2 High-Risk HPV DNA test

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ER -

A new method of screening human papillomavirus genotypes and clinical validation

Abstract

Bibliographical note

Funding

UN SDGs

Research Keywords

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