A MXene-Based Wearable Biosensor System for High-Performance In Vitro Perspiration Analysis

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

26 Scopus Citations
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Author(s)

  • Yongjiu Lei
  • Wenli Zhao
  • Yizhou Zhang
  • Qiu Jiang
  • Antje J. Baeumner
  • Otto S. Wolfbeis
  • Zhong Lin Wang
  • Khaled N. Salama
  • Husam N. Alshareef

Detail(s)

Original languageEnglish
Article number1901190
Journal / PublicationSmall
Volume15
Issue number19
Online published8 Apr 2019
Publication statusPublished - 10 May 2019
Externally publishedYes

Abstract

Wearable electrochemical biosensors for sweat analysis present a promising means for noninvasive biomarker monitoring. However, sweat‐based sensing still poses several challenges, including easy degradation of enzymes and biomaterials with repeated testing, limited detection range and sensitivity of enzyme‐based biosensors caused by oxygen deficiency in sweat, and poor shelf life of sensors using all‐in‐one working electrodes patterned by traditional techniques (e.g., electrodeposition and screen printing). Herein, a stretchable, wearable, and modular multifunctional biosensor is developed, incorporating a novel MXene/Prussian blue (Ti3C2Tx/PB) composite designed for durable and sensitive detection of biomarkers (e.g., glucose and lactate) in sweat. A unique modular design enables a simple exchange of the specific sensing electrode to target the desired analytes. Furthermore, an implemented solid–liquid–air three‐phase interface design leads to superior sensor performance and stability. Typical electrochemical sensitivities of 35.3 µA mm−1 cm−2 for glucose and 11.4 µA mm−1 cm−2 for lactate are achieved using artificial sweat. During in vitro perspiration monitoring of human subjects, the physiochemistry signals (glucose and lactate level) can be measured simultaneously with high sensitivity and good repeatability. This approach represents an important step toward the realization of ultrasensitive enzymatic wearable biosensors for personalized health monitoring.

Research Area(s)

  • biosensor, MXene, perspiration analysis, wearable device

Citation Format(s)

A MXene-Based Wearable Biosensor System for High-Performance In Vitro Perspiration Analysis. / Lei, Yongjiu; Zhao, Wenli; Zhang, Yizhou; Jiang, Qiu; He, Jr-Hau; Baeumner, Antje J.; Wolfbeis, Otto S.; Wang, Zhong Lin; Salama, Khaled N.; Alshareef, Husam N.

In: Small, Vol. 15, No. 19, 1901190, 10.05.2019.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal