A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

Jianzhao Liu; Yanan Yue; Dali Han; Xiao Wang; Y. Fu; Liang Zhang; Guifang Jia; Miao Yu; Zhike Lu; Xin Deng; Qing Dai; Weizhong Chen; Chuan He

doi:10.1038/nchembio.1432

Author(s)

Jianzhao Liu
Yanan Yue
Dali Han
Xiao Wang
Y. Fu
Liang Zhang
Guifang Jia
Miao Yu
Zhike Lu
Qing Dai
Weizhong Chen
Chuan He

Detail(s)

Original language	English
Pages (from-to)	93-95
Journal / Publication	Nature Chemical Biology
Volume	10
Issue number	2
Online published	6 Dec 2013
Publication status	Published - Feb 2014
Externally published	Yes

Link(s)

DOI	DOI https://doi.org/10.1038/nchembio.1432 Final Published version
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Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-84897110592&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(321b45ec-fb6a-4a35-94bf-900954760f8e).html

Abstract

N(⁶)-methyladenosine (m(⁶)A) is the most prevalent and reversible internal modification in mammalian messenger and noncoding RNAs. We report here that human methyltransferase-like 14 (METTL14) catalyzes m(⁶)A RNA methylation. Together with METTL3, the only previously known m(⁶)A methyltransferase, these two proteins form a stable heterodimer core complex of METTL3-METTL14 that functions in cellular m(⁶)A deposition on mammalian nuclear RNAs. WTAP, a mammalian splicing factor, can interact with this complex and affect this methylation.

Citation Format(s)

[ RIS ] [ BibTeX ]

A METTL3-METTL14 complex mediates mammalian nuclear RNA N⁶-adenosine methylation. / Liu, Jianzhao; Yue, Yanan; Han, Dali et al.
In: Nature Chemical Biology, Vol. 10, No. 2, 02.2014, p. 93-95.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

Liu, J, Yue, Y, Han, D, Wang, X, Fu, Y, Zhang, L, Jia, G, Yu, M, Lu, Z, Deng, X, Dai, Q, Chen, W & He, C 2014, 'A METTL3-METTL14 complex mediates mammalian nuclear RNA N⁶-adenosine methylation', Nature Chemical Biology, vol. 10, no. 2, pp. 93-95. https://doi.org/10.1038/nchembio.1432

Liu, J., Yue, Y., Han, D., Wang, X., Fu, Y., Zhang, L., Jia, G., Yu, M., Lu, Z., Deng, X., Dai, Q., Chen, W., & He, C. (2014). A METTL3-METTL14 complex mediates mammalian nuclear RNA N⁶-adenosine methylation. Nature Chemical Biology, 10(2), 93-95. Advance online publication. https://doi.org/10.1038/nchembio.1432

Liu J, Yue Y, Han D, Wang X, Fu Y, Zhang L et al. A METTL3-METTL14 complex mediates mammalian nuclear RNA N⁶-adenosine methylation. Nature Chemical Biology. 2014 Feb;10(2):93-95. Epub 2013 Dec 6. doi: 10.1038/nchembio.1432

Liu, Jianzhao ; Yue, Yanan ; Han, Dali et al. / A METTL3-METTL14 complex mediates mammalian nuclear RNA N⁶-adenosine methylation. In: Nature Chemical Biology. 2014 ; Vol. 10, No. 2. pp. 93-95.