A metal-based tumour necrosis factor-alpha converting enzyme inhibitor

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

21 Scopus Citations
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Author(s)

  • Chung-Hang Leung
  • Li-Juan Liu
  • Lihua Lu
  • Bingyong He
  • Daniel W. J. Kwong
  • Dik-Lung Ma

Detail(s)

Original languageEnglish
Pages (from-to)3973-3976
Journal / PublicationChemical Communications
Volume51
Issue number19
Online published9 Jan 2015
Publication statusPublished - 7 Mar 2015

Abstract

We report herein a novel iridium(iii) complex 1 as an antitumour necrosis factor agent and the first metal-based inhibitor of TACE enzymatic activity. Complex 1 inhibited TNF-α secretion and p38 phosphorylation in human monocytic THP-1 cells. This journal is

Citation Format(s)

A metal-based tumour necrosis factor-alpha converting enzyme inhibitor. / Leung, Chung-Hang; Liu, Li-Juan; Lu, Lihua; He, Bingyong; Kwong, Daniel W. J.; Wong, Chun-Yuen; Ma, Dik-Lung.

In: Chemical Communications, Vol. 51, No. 19, 07.03.2015, p. 3973-3976.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal