A metal-based tumour necrosis factor-alpha converting enzyme inhibitor

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

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Author(s)

  • Chung-Hang Leung
  • Li-Juan Liu
  • Lihua Lu
  • Bingyong He
  • Daniel W. J. Kwong
  • Dik-Lung Ma

Detail(s)

Original languageEnglish
Pages (from-to)3973-3976
Journal / PublicationChemical Communications
Volume51
Issue number19
Online published9 Jan 2015
Publication statusPublished - 7 Mar 2015

Link(s)

DOI

DOI
Check@CityULib
Link to Scopus https://www.scopus.com/record/display.uri?eid=2-s2.0-84923323824&origin=recordpage
Permanent Link https://scholars.cityu.edu.hk/en/publications/publication(c985ad29-eb24-492f-a2ab-0a99eec20ebd).html

Abstract

We report herein a novel iridium(iii) complex 1 as an antitumour necrosis factor agent and the first metal-based inhibitor of TACE enzymatic activity. Complex 1 inhibited TNF-α secretion and p38 phosphorylation in human monocytic THP-1 cells. This journal is

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Publication fingerprints text

100
Iridium Medicine & Life Sciences
83
Corrosion inhibitor... Engineering & Materials S...
83
Enzyme Inhibitors Medicine & Life Sciences
62
Necrosis Medicine & Life Sciences
60
Tumor Necrosis Fact... Medicine & Life Sciences
58
Metals Medicine & Life Sciences
57
Phosphorylation Medicine & Life Sciences
30
Enzymes Engineering & Materials S...
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Citation Format(s)

[ RIS ] [ BibTeX ]

A metal-based tumour necrosis factor-alpha converting enzyme inhibitor. / Leung, Chung-Hang; Liu, Li-Juan; Lu, Lihua et al.

In: Chemical Communications, Vol. 51, No. 19, 07.03.2015, p. 3973-3976.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review