A lysosome-specific two-photon phosphorescent binuclear cyclometalated platinum(II) probe for in vivo imaging of live neurons

Yu-Man Ho; Ngan-Pan Bennett Au; Ka-Leung Wong; Chris Tsz-Leung Chan; Wai-Ming Kwok; Ga-Lai Law; Kwong-Kit Tang; Wai-Yeung Wong; Chi-Him Eddie Ma; Michael Hon-Wah Lam

doi:10.1039/c3cc48934e

A lysosome-specific two-photon phosphorescent binuclear cyclometalated platinum(II) probe for in vivo imaging of live neurons

Yu-Man Ho, Ngan-Pan Bennett Au, Ka-Leung Wong, Chris Tsz-Leung Chan, Wai-Ming Kwok, Ga-Lai Law, Kwong-Kit Tang, Wai-Yeung Wong, Chi-Him Eddie Ma, Michael Hon-Wah Lam

Centre for Biosystems, Neuroscience, and Nanotechnology

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

42 Citations (Scopus)

Abstract

Real-time tracking of fast axonal transport of acidic vesicles in live adult mouse dorsal root ganglion (DRG) and cortical neurons in brain slices was visualized by the use of binuclear cycloplatinated complexes, {[Pt(L ₁)]₂(μ-dppm)}²⁺ (1) and {[Pt(L ₂)]₂(μ-dppm)}²⁺ (2), as lysosome-specific two-photon imaging probes. © the Partner Organisations 2014.

Original language	English
Pages (from-to)	4161-4163
Journal	Chemical Communications
Volume	50
Issue number	32
Online published	3 Jan 2014
DOIs	https://doi.org/10.1039/c3cc48934e
Publication status	Published - 25 Apr 2014

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title = "A lysosome-specific two-photon phosphorescent binuclear cyclometalated platinum(II) probe for in vivo imaging of live neurons",

abstract = "Real-time tracking of fast axonal transport of acidic vesicles in live adult mouse dorsal root ganglion (DRG) and cortical neurons in brain slices was visualized by the use of binuclear cycloplatinated complexes, {[Pt(L 1)]2(μ-dppm)}2+ (1) and {[Pt(L 2)]2(μ-dppm)}2+ (2), as lysosome-specific two-photon imaging probes. {\textcopyright} the Partner Organisations 2014.",

author = "Yu-Man Ho and Au, {Ngan-Pan Bennett} and Ka-Leung Wong and Chan, {Chris Tsz-Leung} and Wai-Ming Kwok and Ga-Lai Law and Kwong-Kit Tang and Wai-Yeung Wong and Ma, {Chi-Him Eddie} and Lam, {Michael Hon-Wah}",

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T1 - A lysosome-specific two-photon phosphorescent binuclear cyclometalated platinum(II) probe for in vivo imaging of live neurons

AU - Ho, Yu-Man

AU - Au, Ngan-Pan Bennett

AU - Wong, Ka-Leung

AU - Chan, Chris Tsz-Leung

AU - Kwok, Wai-Ming

AU - Law, Ga-Lai

AU - Tang, Kwong-Kit

AU - Wong, Wai-Yeung

AU - Ma, Chi-Him Eddie

AU - Lam, Michael Hon-Wah

PY - 2014/4/25

Y1 - 2014/4/25

N2 - Real-time tracking of fast axonal transport of acidic vesicles in live adult mouse dorsal root ganglion (DRG) and cortical neurons in brain slices was visualized by the use of binuclear cycloplatinated complexes, {[Pt(L 1)]2(μ-dppm)}2+ (1) and {[Pt(L 2)]2(μ-dppm)}2+ (2), as lysosome-specific two-photon imaging probes. © the Partner Organisations 2014.

AB - Real-time tracking of fast axonal transport of acidic vesicles in live adult mouse dorsal root ganglion (DRG) and cortical neurons in brain slices was visualized by the use of binuclear cycloplatinated complexes, {[Pt(L 1)]2(μ-dppm)}2+ (1) and {[Pt(L 2)]2(μ-dppm)}2+ (2), as lysosome-specific two-photon imaging probes. © the Partner Organisations 2014.

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UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-84897008214&origin=recordpage

U2 - 10.1039/c3cc48934e

DO - 10.1039/c3cc48934e

M3 - RGC 21 - Publication in refereed journal

C2 - 24418895

SN - 0009-241X

VL - 50

SP - 4161

EP - 4163

JO - Chemical Communications

JF - Chemical Communications

IS - 32

ER -

A lysosome-specific two-photon phosphorescent binuclear cyclometalated platinum(II) probe for in vivo imaging of live neurons

Abstract

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ADDITIONS & CORRECTIONS: A lysosome-specific two-photon phosphorescent binuclear cyclometalated platinum(II) probe for in vivo imaging of live neurons

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