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A LDH-Based Supramolecular Photosensitizer-Functionalized Bioactive Glass Scaffold for Integrated Postoperative Osteosarcoma Recurrence Prevention and Bone Regeneration

  • Tao Wang (Co-first Author)
  • , Yixin Bian (Co-first Author)
  • , Tingting Hu (Co-first Author)
  • , Mengyang Li
  • , Yuqin Tan
  • , Yu Yang
  • , Xiaolan Jian
  • , Xisheng Weng*
  • , Chaoliang Tan*
  • , Ruizheng Liang*
    • *Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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Abstract

Layered double hydroxide (LDH)-based materials have been explored as efficient photosensitizers for photodynamic therapy (PDT) or functional agents for bone regeneration, holding great promise in the synergistic PDT-mediated osteosarcoma treatment and bone reconstruction. Herein, we report the functionalization of 5-iodoisophthalic acid (I-IPA)-intercalated MgZnAl-LDH onto bioactive glass scaffold (BGS) to construct a bifunctional composite scaffold (BGS/I-LDH) for integrated osteosarcoma treatment and bone regeneration. The surface functionalization of I-LDH onto BGS confers BGS/I-LDH high-efficiency reactive oxygen species generation performance under 1270 nm laser irradiation, resulting in a singlet oxygen quantum yield up to 1.53, which is significantly superior to that of previously reported NIR-excited PSs. Moreover, thanks to the sustained release of Mg2+ and Zn2+ ions from I-LDH, BGS/I-LDH exhibits exceptional anti-osteosarcoma and osteogenic properties with 3.8-fold bone volume, 3.0-fold bone mineral density, and 11.4-fold new bone mass increments compared with the pristine BGS, which is remarkably more preponderant than other previously reported modified BGS. © 2026 The Author(s). Advanced Science published by Wiley-VCH GmbH
Original languageEnglish
Article numbere24296
JournalAdvanced Science
Online published9 Feb 2026
DOIs
Publication statusOnline published - 9 Feb 2026

Funding

R.L. thanks the funding support from the National Natural Science Foundation of China-Excellent Young Scientists Fund (52322317), the National Key Research and Development Program of China (2024YFA1211600) and the Interdisciplinary Research Center of Beijing University of Chemical Technology (No. XK2025-05). C.T. thanks the funding support from the Shenzhen Basic Research General Program (No. JCYJ20250604184523030) from the Science, Technology and Innovation Bureau of Shenzhen Municipality, the Start-Up Grant (Project No. 9610710) from City University of Hong Kong, and ITC via the Hong Kong Branch of National Precious Metals Material Engineering Research Center (NPMM). X.W. thanks the funding support from the National Natural Science Foundation of China (Grant ID: 81630064).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Research Keywords

  • bioactive glass scaffolds
  • bone regeneration
  • layered double hydroxides
  • osteosarcoma treatment
  • photodynamic therapy

Publisher's Copyright Statement

  • This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/

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