TY - JOUR
T1 - A laser-engraved wearable sensor for sensitive detection of uric acid and tyrosine in sweat
AU - Yang, Yiran
AU - Song, Yu
AU - Bo, Xiangjie
AU - Min, Jihong
AU - Pak, On Shun
AU - Zhu, Lailai
AU - Wang, Minqiang
AU - Tu, Jiaobing
AU - Kogan, Adam
AU - Zhang, Haixia
AU - Hsiai, Tzung K.
AU - Li, Zhaoping
AU - Gao, Wei
PY - 2020/2
Y1 - 2020/2
N2 - Wearable sweat sensors have the potential to provide continuous measurements of useful biomarkers. However, current sensors cannot accurately detect low analyte concentrations, lack multimodal sensing or are difficult to fabricate at large scale. We report an entirely laser-engraved sensor for simultaneous sweat sampling, chemical sensing and vital-sign monitoring. We demonstrate continuous detection of temperature, respiration rate and low concentrations of uric acid and tyrosine, analytes associated with diseases such as gout and metabolic disorders. We test the performance of the device in both physically trained and untrained subjects under exercise and after a protein-rich diet. We also evaluate its utility for gout monitoring in patients and healthy controls through a purine-rich meal challenge. Levels of uric acid in sweat were higher in patients with gout than in healthy individuals, and a similar trend was observed in serum. © The Author(s), under exclusive licence to Springer Nature America, Inc. 2019
AB - Wearable sweat sensors have the potential to provide continuous measurements of useful biomarkers. However, current sensors cannot accurately detect low analyte concentrations, lack multimodal sensing or are difficult to fabricate at large scale. We report an entirely laser-engraved sensor for simultaneous sweat sampling, chemical sensing and vital-sign monitoring. We demonstrate continuous detection of temperature, respiration rate and low concentrations of uric acid and tyrosine, analytes associated with diseases such as gout and metabolic disorders. We test the performance of the device in both physically trained and untrained subjects under exercise and after a protein-rich diet. We also evaluate its utility for gout monitoring in patients and healthy controls through a purine-rich meal challenge. Levels of uric acid in sweat were higher in patients with gout than in healthy individuals, and a similar trend was observed in serum. © The Author(s), under exclusive licence to Springer Nature America, Inc. 2019
UR - http://www.scopus.com/inward/record.url?scp=85075461708&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85075461708&origin=recordpage
U2 - 10.1038/s41587-019-0321-x
DO - 10.1038/s41587-019-0321-x
M3 - RGC 21 - Publication in refereed journal
SN - 1087-0156
VL - 38
SP - 217
EP - 224
JO - Nature Biotechnology
JF - Nature Biotechnology
IS - 2
ER -