A highly versatile platform based on geometrically well-defined 3D DNA nanostructures for selective recognition and positioning of multiplex targets

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

8 Scopus Citations
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Author(s)

  • Qi Gao
  • Man Ching Cheung
  • Hoi Man Leung
  • Hanadi F. Sleiman

Detail(s)

Original languageEnglish
Pages (from-to)18291-18295
Journal / PublicationNanoscale
Volume8
Issue number43
Publication statusPublished - 21 Nov 2016

Abstract

We develop a versatile recognition system based on 3D triangular-shaped DNA nanotubes by integrating three different aptamer sequences along the three edges. This would allow multiple binding activities to be combined into a single system. The versatility of this nanotube platform can also provide a framework for spatial orientation and positioning of different aptamer-binding ligands in a 'pea-pod' architecture.

Citation Format(s)

A highly versatile platform based on geometrically well-defined 3D DNA nanostructures for selective recognition and positioning of multiplex targets. / Dai, Ziwen; Gao, Qi; Cheung, Man Ching; Leung, Hoi Man; Lau, Terrence Chi Kong; Sleiman, Hanadi F.; Lai, King Wai Chiu; Lo, Pik Kwan.

In: Nanoscale, Vol. 8, No. 43, 21.11.2016, p. 18291-18295.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal