A Highly Efficient Tumor-Targeting Nanoprobe with a Novel Cell Membrane Permeability Mechanism

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

57 Scopus Citations
View graph of relations

Author(s)

  • Zhendong Lei
  • Lin Ding
  • Chenjie Yao
  • Fengfeng Mo
  • Chenchen Li
  • Yanan Huang
  • Xuelian Yin
  • Min Li
  • Jinliang Liu
  • Changquan Ling
  • Yanli Wang

Detail(s)

Original languageEnglish
Article number1807456
Journal / PublicationAdvanced Materials
Volume31
Issue number12
Publication statusPublished - 22 Mar 2019
Externally publishedYes

Abstract

Efficient tumor targeting has been a great challenge in the clinic for a very long time. The traditional targeting methods based on enhanced permeability and retention (EPR) effects show only an ≈5% targeting rate. To solve this problem, a new graphene-based tumor cell nuclear targeting fluorescent nanoprobe (GTTN), with a new tumor-targeting mechanism, is developed. GTTN is a graphene-like single-crystalline structure amphiphilic fluorescent probe with a periphery that is functionalized by sulfonic and hydroxyl groups. This probe has the characteristic of specific tumor cell targeting, as it can directly cross the cell membrane and specifically target to the tumor cell nucleus by the changed permeability of the tumor cell membranes in the tumor tissue. This new targeting mechanism is named the cell membrane permeability targeting (CMPT) mechanism, which is very different from the EPR effect. These probes can recognize tumor tissue at a very early stage and track the invasion and metastasis of tumor cells at the single cell level. The tumor-targeting rate is improved from less than 5% to more than 50%. This achievement in efficient and accurate tumor cell targeting will speed up the arrival of a new era of tumor diagnosis and treatment. © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Research Area(s)

  • cell membrane permeability, fluorescent nanoprobes, tumor cell nuclear targeting

Bibliographic Note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Citation Format(s)

A Highly Efficient Tumor-Targeting Nanoprobe with a Novel Cell Membrane Permeability Mechanism. / Lei, Zhendong; Ding, Lin; Yao, Chenjie et al.
In: Advanced Materials, Vol. 31, No. 12, 1807456, 22.03.2019.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review