A Highly Efficient Tumor-Targeting Nanoprobe with a Novel Cell Membrane Permeability Mechanism
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Author(s)
Detail(s)
Original language | English |
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Article number | 1807456 |
Journal / Publication | Advanced Materials |
Volume | 31 |
Issue number | 12 |
Publication status | Published - 22 Mar 2019 |
Externally published | Yes |
Link(s)
Abstract
Efficient tumor targeting has been a great challenge in the clinic for a very long time. The traditional targeting methods based on enhanced permeability and retention (EPR) effects show only an ≈5% targeting rate. To solve this problem, a new graphene-based tumor cell nuclear targeting fluorescent nanoprobe (GTTN), with a new tumor-targeting mechanism, is developed. GTTN is a graphene-like single-crystalline structure amphiphilic fluorescent probe with a periphery that is functionalized by sulfonic and hydroxyl groups. This probe has the characteristic of specific tumor cell targeting, as it can directly cross the cell membrane and specifically target to the tumor cell nucleus by the changed permeability of the tumor cell membranes in the tumor tissue. This new targeting mechanism is named the cell membrane permeability targeting (CMPT) mechanism, which is very different from the EPR effect. These probes can recognize tumor tissue at a very early stage and track the invasion and metastasis of tumor cells at the single cell level. The tumor-targeting rate is improved from less than 5% to more than 50%. This achievement in efficient and accurate tumor cell targeting will speed up the arrival of a new era of tumor diagnosis and treatment. © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Research Area(s)
- cell membrane permeability, fluorescent nanoprobes, tumor cell nuclear targeting
Bibliographic Note
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Citation Format(s)
A Highly Efficient Tumor-Targeting Nanoprobe with a Novel Cell Membrane Permeability Mechanism. / Lei, Zhendong; Ding, Lin; Yao, Chenjie et al.
In: Advanced Materials, Vol. 31, No. 12, 1807456, 22.03.2019.
In: Advanced Materials, Vol. 31, No. 12, 1807456, 22.03.2019.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review