A graphene quantum dot photodynamic therapy agent with high singlet oxygen generation

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Jiechao Ge
  • Minhuan Lan
  • Bingjiang Zhou
  • Weimin Liu
  • Liang Guo
  • Hui Wang
  • Qingyan Jia
  • Guangle Niu
  • Xing Huang
  • Hangyue Zhou
  • Xiangmin Meng
  • Pengfei Wang
  • Xiaodong Han

Detail(s)

Original languageEnglish
Article number4596
Journal / PublicationNature Communications
Volume5
Online published8 Aug 2014
Publication statusPublished - 2014

Link(s)

Abstract

Clinical applications of current photodynamic therapy (PDT) agents are often limited by their low singlet oxygen (1O2) quantum yields, as well as by photobleaching and poor biocompatibility. Here we present a new PDT agent based on graphene quantum dots (GQDs) that can produce 1O2 via a multistate sensitization process, resulting in a quantum yield of similar to 1.3, the highest reported for PDT agents. The GQDs also exhibit a broad absorption band spanning the UV region and the entire visible region and a strong deep-red emission. Through in vitro and in vivo studies, we demonstrate that GQDs can be used as PDT agents, simultaneously allowing imaging and providing a highly efficient cancer therapy. The present work may lead to a new generation of carbon-based nanomaterial PDT agents with overall performance superior to conventional agents in terms of 1O2 quantum yield, water dispersibility, photo-and pH-stability, and biocompatibility.

Research Area(s)

Citation Format(s)

A graphene quantum dot photodynamic therapy agent with high singlet oxygen generation. / Ge, Jiechao; Lan, Minhuan; Zhou, Bingjiang et al.
In: Nature Communications, Vol. 5, 4596, 2014.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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