A G-quadruplex structure in microRNA interferes with messenger RNA recognition and controls gene expression

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Detail(s)

Original languageEnglish
Pages (from-to)8230-8233
Journal / PublicationChemical Communications
Volume59
Issue number53
Online published13 Jun 2023
Publication statusPublished - 7 Jul 2023

Abstract

We identify and characterize an RNA G-quadruplex (rG4) structure motif in the human microRNA 638 (hsa-miR-638). We investigate the formation and role of this rG4 in vitro and in cells, and reveal that it inhibits the miR-638 and MEF2C messenger RNA interaction and controls gene expression at the translational level. © The Royal Society of Chemistry 2023

Research Area(s)

  • GENOMICS