A G-quadruplex structure in microRNA interferes with messenger RNA recognition and controls gene expression

Kaixin Lyu; Chun Kit Kwok

doi:10.1039/d3cc01549a

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Detail(s)

Original language	English
Pages (from-to)	8230-8233
Journal / Publication	Chemical Communications
Volume	59
Issue number	53
Online published	13 Jun 2023
Publication status	Published - 7 Jul 2023

Link(s)

DOI	DOI https://doi.org/10.1039/d3cc01549a Final Published version
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Attachment(s)	Documents 157725102.pdf Post-print, 681 KB, PDF Publisher's Copyright Statement COPYRIGHT TERMS OF DEPOSITED POSTPRINT FILE: This journal is © The Royal Society of Chemistry 2023. This is the accepted version of a paper published in Chemical Communications. This paper has been peer-reviewed but does not include the final publisher proof-corrections or journal pagination. Lyu, K., & Kwok, C. K. (2023). A G-quadruplex structure in microRNA interferes with messenger RNA recognition and controls gene expression. Chemical Communications, 59(53), 8230-8233. https://doi.org/10.1039/d3cc01549a.
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-85163473883&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(77d08693-e187-489d-b0db-2a690afeeaf3).html

Abstract

We identify and characterize an RNA G-quadruplex (rG4) structure motif in the human microRNA 638 (hsa-miR-638). We investigate the formation and role of this rG4 in vitro and in cells, and reveal that it inhibits the miR-638 and MEF2C messenger RNA interaction and controls gene expression at the translational level. © The Royal Society of Chemistry 2023