A glutathione-activated phthalocyanine-based photosensitizer for photodynamic therapy
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
Author(s)
Detail(s)
| Original language | English |
|---|---|
| Pages (from-to) | 6241-6245 |
| Journal / Publication | Chemistry - A European Journal |
| Volume | 20 |
| Issue number | 21 |
| Publication status | Published - 19 May 2014 |
| Externally published | Yes |
Link(s)
Abstract
A zinc(II) phthalocyanine substituted with a 2,4-dinitrobenzenesulfonate group has been prepared. Its fluorescence emission and reactive oxygen species generation can be greatly enhanced by glutathione in phosphate-buffered saline and inside MCF-7 cells. This compound thus functions as a highly efficient molecular-based activatable photosensitizer. Light therapy: Fluorescence emission and reactive oxygen species generation are greatly enhanced in a molecular phthalocyanine-quencher system upon interaction with glutathione (see figure). Its activation has also been demonstrated in vivo. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Research Area(s)
- glutathione, photodynamic therapy, photosensitizers, phthalocyanines, singlet oxygen
Citation Format(s)
A glutathione-activated phthalocyanine-based photosensitizer for photodynamic therapy. / He, Hui; Lo, Pui-Chi; Ng, Dennis K. P.
In: Chemistry - A European Journal, Vol. 20, No. 21, 19.05.2014, p. 6241-6245.Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
