A glutathione-activated phthalocyanine-based photosensitizer for photodynamic therapy

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)6241-6245
Journal / PublicationChemistry - A European Journal
Volume20
Issue number21
Publication statusPublished - 19 May 2014
Externally publishedYes

Abstract

A zinc(II) phthalocyanine substituted with a 2,4-dinitrobenzenesulfonate group has been prepared. Its fluorescence emission and reactive oxygen species generation can be greatly enhanced by glutathione in phosphate-buffered saline and inside MCF-7 cells. This compound thus functions as a highly efficient molecular-based activatable photosensitizer. Light therapy: Fluorescence emission and reactive oxygen species generation are greatly enhanced in a molecular phthalocyanine-quencher system upon interaction with glutathione (see figure). Its activation has also been demonstrated in vivo. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Research Area(s)

  • glutathione, photodynamic therapy, photosensitizers, phthalocyanines, singlet oxygen