A glutathione responsive photosensitizer based on hypocrellin B for photodynamic therapy

Zhe Yu; Tian Liu; Xiuli Zheng; Yanping Wang; Jie Sha; Lin Shan; Tong Mu; Wenjun Zhang; Chun−Sing Lee; Weimin Liu; Pengfei Wang

doi:10.1016/j.saa.2024.125052

Author(s)

Zhe Yu
Tian Liu
Xiuli Zheng
Yanping Wang
Jie Sha
Lin Shan
Tong Mu
Weimin Liu
Pengfei Wang

Related Research Unit(s)

Detail(s)

Original language	English
Article number	125052
Journal / Publication	Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Volume	325
Online published	29 Aug 2024
Publication status	Published - 15 Jan 2025

Link(s)

DOI	DOI https://doi.org/10.1016/j.saa.2024.125052 Final Published version
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Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-85202926080&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(ee09ca9c-5d7b-4b6b-88bd-0a3325c11403).html

Abstract

As a typical natural photosensitizer, hypocrellin B (HB) offers the advantages of high molar extinction coefficient, high phototoxicity, low dark toxicity, and fast metabolism in vivo. However, the lack of tumor specificity hinders its clinical applications. Herein, we designed and synthesized a glutathione (GSH) responsive photosensitizer based on HB. The 7 − nitro − 2,1,3 − benzoxadiazole (NBD) covalently connected to HB not only served as a fluorescence quenching group but also as a GSH activating group. The photosensitizer HB−NBD showed almost no fluorescence and singlet oxygen generation as a result of the photoinduced electron transfer between HB and NBD. The designed photosensitizer HB−NBD can be activated by GSH in solutions and cancer cells, and then obtain recuperative fluorescence and photosensitive activity. © 2024 Elsevier B.V.

Research Area(s)

Cancer cells, Glutathione, Hypocrellin B, Photocytotoxicity, Photodynamic therapy

SDG 3 - Good Health and Well-being

Citation Format(s)

[ RIS ] [ BibTeX ]

A glutathione responsive photosensitizer based on hypocrellin B for photodynamic therapy. / Yu, Zhe; Liu, Tian; Zheng, Xiuli et al.
In: Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, Vol. 325, 125052, 15.01.2025.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Yu, Z, Liu, T, Zheng, X, Wang, Y, Sha, J, Shan, L, Mu, T, Zhang, W , Lee, CS, Liu, W & Wang, P 2025, 'A glutathione responsive photosensitizer based on hypocrellin B for photodynamic therapy', Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, vol. 325, 125052. https://doi.org/10.1016/j.saa.2024.125052

Yu, Z., Liu, T., Zheng, X., Wang, Y., Sha, J., Shan, L., Mu, T., Zhang, W., Lee, CS., Liu, W., & Wang, P. (2025). A glutathione responsive photosensitizer based on hypocrellin B for photodynamic therapy. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 325, Article 125052. https://doi.org/10.1016/j.saa.2024.125052

Yu Z, Liu T, Zheng X, Wang Y, Sha J, Shan L et al. A glutathione responsive photosensitizer based on hypocrellin B for photodynamic therapy. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy. 2025 Jan 15;325:125052. Epub 2024 Aug 29. doi: 10.1016/j.saa.2024.125052

Yu, Zhe ; Liu, Tian ; Zheng, Xiuli et al. / A glutathione responsive photosensitizer based on hypocrellin B for photodynamic therapy. In: Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy. 2025 ; Vol. 325.