TY - JOUR
T1 - A glutathione responsive photosensitizer based on hypocrellin B for photodynamic therapy
AU - Yu, Zhe
AU - Liu, Tian
AU - Zheng, Xiuli
AU - Wang, Yanping
AU - Sha, Jie
AU - Shan, Lin
AU - Mu, Tong
AU - Zhang, Wenjun
AU - Lee, Chun−Sing
AU - Liu, Weimin
AU - Wang, Pengfei
PY - 2025/1/15
Y1 - 2025/1/15
N2 - As a typical natural photosensitizer, hypocrellin B (HB) offers the advantages of high molar extinction coefficient, high phototoxicity, low dark toxicity, and fast metabolism in vivo. However, the lack of tumor specificity hinders its clinical applications. Herein, we designed and synthesized a glutathione (GSH) responsive photosensitizer based on HB. The 7 − nitro − 2,1,3 − benzoxadiazole (NBD) covalently connected to HB not only served as a fluorescence quenching group but also as a GSH activating group. The photosensitizer HB−NBD showed almost no fluorescence and singlet oxygen generation as a result of the photoinduced electron transfer between HB and NBD. The designed photosensitizer HB−NBD can be activated by GSH in solutions and cancer cells, and then obtain recuperative fluorescence and photosensitive activity. © 2024 Elsevier B.V.
AB - As a typical natural photosensitizer, hypocrellin B (HB) offers the advantages of high molar extinction coefficient, high phototoxicity, low dark toxicity, and fast metabolism in vivo. However, the lack of tumor specificity hinders its clinical applications. Herein, we designed and synthesized a glutathione (GSH) responsive photosensitizer based on HB. The 7 − nitro − 2,1,3 − benzoxadiazole (NBD) covalently connected to HB not only served as a fluorescence quenching group but also as a GSH activating group. The photosensitizer HB−NBD showed almost no fluorescence and singlet oxygen generation as a result of the photoinduced electron transfer between HB and NBD. The designed photosensitizer HB−NBD can be activated by GSH in solutions and cancer cells, and then obtain recuperative fluorescence and photosensitive activity. © 2024 Elsevier B.V.
KW - Cancer cells
KW - Glutathione
KW - Hypocrellin B
KW - Photocytotoxicity
KW - Photodynamic therapy
UR - http://www.scopus.com/inward/record.url?scp=85202926080&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85202926080&origin=recordpage
U2 - 10.1016/j.saa.2024.125052
DO - 10.1016/j.saa.2024.125052
M3 - RGC 21 - Publication in refereed journal
SN - 1386-1425
VL - 325
JO - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
JF - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
M1 - 125052
ER -
