A general palladium-catalyzed method for alkylation of heteroarenes using secondary and tertiary alkyl halides

Xiaojin Wu, Jessica Wei Ting See, Kai Xu, Hajime Hirao, Julien Roger, Jean-Cyrille Hierso, Jianrong Zhou*

*Corresponding author for this work

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

125 Citations (Scopus)

Abstract

A general alkylation of heterocycles using a simple palladium catalyst is reported. Most classes of heterocycles, including indoles and pyridines, efficiently coupled with unactivated secondary and tertiary alkyl halides. An alkyl radical addition to neutral heteroarenes is most likely involved.
Original languageEnglish
Pages (from-to)13573-13577
JournalAngewandte Chemie - International Edition
Volume53
Issue number49
DOIs
Publication statusPublished - 1 Dec 2014
Externally publishedYes

Research Keywords

  • Alkyl radicals
  • C-H activation
  • Heterocycles
  • Palladium
  • Single electron transfer

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