A fluorogenic H2S-triggered prodrug based on thiolysis of the NBD amine

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review

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Author(s)

  • Yonghui Xie
  • Haojie Huang
  • Ismail Ismail
  • Long Yi
  • Zhen Xi

Detail(s)

Original languageEnglish
Article number126627
Journal / PublicationBioorganic and Medicinal Chemistry Letters
Volume29
Issue number19
Early online date17 Aug 2019
Publication statusPublished - 1 Oct 2019

Abstract

Based on thiolysis of the NBD amine, a H2S-triggered prodrug has been designed and synthesized for localized production of ciprofloxacin under micromolar H2S. Activation of the prodrug can be monitored through fluorescence in real-time. We envision that thiolysis of the NBD amine could be readily used for development of other H2S-triggered prodrugs in the future.

Research Area(s)

  • Ciprofloxacin, H2S-triggered, NBD amine, Prodrug

Citation Format(s)

A fluorogenic H2S-triggered prodrug based on thiolysis of the NBD amine. / Xie, Yonghui; Huang, Haojie; Ismail, Ismail; Sun, Hongyan; Yi, Long; Xi, Zhen.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 29, No. 19, 126627, 01.10.2019.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review