A fluorescent probe for the discrimination of oxidation states of palladium

Lijun Jiang; Ho-Nam Mak; Edward R. H. Walter; Wing-Tak Wong; Ka-Leung Wong; Nicholas J. Long

doi:10.1039/d1sc01616d

A fluorescent probe for the discrimination of oxidation states of palladium

Lijun Jiang (Co-first Author), Ho-Nam Mak (Co-first Author), Edward R. H. Walter, Wing-Tak Wong^*, Ka-Leung Wong^*, Nicholas J. Long^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

16 Citations (Scopus)

Abstract

Palladium-based catalysts are widely used in pharmaceutical industries, which can sometimes cause palladium contamination in pharmaceutical drug manufacture. It is important to separately quantify the different oxidation states of palladium (Pd⁰ and Pd²⁺) in pharmaceuticals as they react with scavengers differently. Although palladium sensors have been under intense investigation, oxidation state differentiators are very rare. Here, we report a simple porphyrin–coumarin conjugate, PPIX-L2, that can selectively discriminate between the oxidation states of palladium. The reaction of PPIX-L2 with Pd⁰ showed a 24-fold fluorescence increase of the coumarin emission, meanwhile, the presence of Pd²⁺ led to a 98% quenching of the porphyrin emission. Fluorescent responses of PPIX-L2 towards Pd⁰ and Pd²⁺ are specific, and its sensitivity towards both palladium species is significantly increased with a detection limit of 75 nM and 382 nM for Pd⁰ and Pd²⁺ respectively. © 2021 The Author(s). Published by the Royal Society of Chemistry.

Original language	English
Pages (from-to)	9977-9982
Number of pages	6
Journal	Chemical Science
Volume	12
Issue number	29
Online published	24 Jun 2021
DOIs	https://doi.org/10.1039/d1sc01616d
Publication status	Published - 7 Aug 2021
Externally published	Yes

Funding

N. J. L. gratefully acknowledges the support of a Royal Society Wolfson Research Merit Award. K.-L. W. acknowledges the support from the Dr Mok Man Huang Endowed Professorship in HKBU Chemistry. We thank Dr P.-K. So (PolyU University Research Facility in Life Science) for technical assistance in MALDI-TOF mass spectrum. This work was supported by grants from Hong Kong Research Grant Council (HKBU 12300019).

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This full text is made available under CC-BY-NC 3.0. https://creativecommons.org/licenses/by-nc/3.0/

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RGC-funded

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title = "A fluorescent probe for the discrimination of oxidation states of palladium",

abstract = "Palladium-based catalysts are widely used in pharmaceutical industries, which can sometimes cause palladium contamination in pharmaceutical drug manufacture. It is important to separately quantify the different oxidation states of palladium (Pd0 and Pd2+) in pharmaceuticals as they react with scavengers differently. Although palladium sensors have been under intense investigation, oxidation state differentiators are very rare. Here, we report a simple porphyrin–coumarin conjugate, PPIX-L2, that can selectively discriminate between the oxidation states of palladium. The reaction of PPIX-L2 with Pd0 showed a 24-fold fluorescence increase of the coumarin emission, meanwhile, the presence of Pd2+ led to a 98% quenching of the porphyrin emission. Fluorescent responses of PPIX-L2 towards Pd0 and Pd2+ are specific, and its sensitivity towards both palladium species is significantly increased with a detection limit of 75 nM and 382 nM for Pd0 and Pd2+ respectively. {\textcopyright} 2021 The Author(s). Published by the Royal Society of Chemistry.",

author = "Lijun Jiang and Ho-Nam Mak and Walter, {Edward R. H.} and Wing-Tak Wong and Ka-Leung Wong and Long, {Nicholas J.}",

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TY - JOUR

T1 - A fluorescent probe for the discrimination of oxidation states of palladium

AU - Jiang, Lijun

AU - Mak, Ho-Nam

AU - Walter, Edward R. H.

AU - Wong, Wing-Tak

AU - Wong, Ka-Leung

AU - Long, Nicholas J.

PY - 2021/8/7

Y1 - 2021/8/7

N2 - Palladium-based catalysts are widely used in pharmaceutical industries, which can sometimes cause palladium contamination in pharmaceutical drug manufacture. It is important to separately quantify the different oxidation states of palladium (Pd0 and Pd2+) in pharmaceuticals as they react with scavengers differently. Although palladium sensors have been under intense investigation, oxidation state differentiators are very rare. Here, we report a simple porphyrin–coumarin conjugate, PPIX-L2, that can selectively discriminate between the oxidation states of palladium. The reaction of PPIX-L2 with Pd0 showed a 24-fold fluorescence increase of the coumarin emission, meanwhile, the presence of Pd2+ led to a 98% quenching of the porphyrin emission. Fluorescent responses of PPIX-L2 towards Pd0 and Pd2+ are specific, and its sensitivity towards both palladium species is significantly increased with a detection limit of 75 nM and 382 nM for Pd0 and Pd2+ respectively. © 2021 The Author(s). Published by the Royal Society of Chemistry.

AB - Palladium-based catalysts are widely used in pharmaceutical industries, which can sometimes cause palladium contamination in pharmaceutical drug manufacture. It is important to separately quantify the different oxidation states of palladium (Pd0 and Pd2+) in pharmaceuticals as they react with scavengers differently. Although palladium sensors have been under intense investigation, oxidation state differentiators are very rare. Here, we report a simple porphyrin–coumarin conjugate, PPIX-L2, that can selectively discriminate between the oxidation states of palladium. The reaction of PPIX-L2 with Pd0 showed a 24-fold fluorescence increase of the coumarin emission, meanwhile, the presence of Pd2+ led to a 98% quenching of the porphyrin emission. Fluorescent responses of PPIX-L2 towards Pd0 and Pd2+ are specific, and its sensitivity towards both palladium species is significantly increased with a detection limit of 75 nM and 382 nM for Pd0 and Pd2+ respectively. © 2021 The Author(s). Published by the Royal Society of Chemistry.

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U2 - 10.1039/d1sc01616d

DO - 10.1039/d1sc01616d

M3 - RGC 21 - Publication in refereed journal

SN - 2041-6520

VL - 12

SP - 9977

EP - 9982

JO - Chemical Science

JF - Chemical Science

IS - 29

ER -

A fluorescent probe for the discrimination of oxidation states of palladium

Abstract

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