A dynamic model of chemoattractant-induced cell migration

Hao Yang; Xue Gou; Yong Wang; Tarek M. Fahmy; Anskar Y.-H. Leung; Jian Lu; Dong Sun

doi:10.1016/j.bpj.2014.12.060

A dynamic model of chemoattractant-induced cell migration

Hao Yang, Xue Gou, Yong Wang, Tarek M. Fahmy, Anskar Y.-H. Leung, Jian Lu, Dong Sun^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

33 Citations (Scopus)

Abstract

Cell migration refers to a directional cell movement in response to chemoattractant stimulation. In this work, we developed a cell-migration model by mimicking in vivo migration using optically manipulated chemoattractant-loaded microsources. The model facilitates a quantitative characterization of the relationship among the protrusion force, cell motility, and chemoattractant gradient for the first time (to our knowledge). We verified the correctness of the model using migrating leukemia cancer Jurkat cells. The results show that one can achieve the ideal migrating capacity by choosing the appropriate chemoattractant gradient and concentration at the leading edge of the cell.

Original language	English
Pages (from-to)	1645-1651
Journal	Biophysical Journal
Volume	108
Issue number	7
Online published	7 Apr 2015
DOIs	https://doi.org/10.1016/j.bpj.2014.12.060
Publication status	Published - 7 Apr 2015

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title = "A dynamic model of chemoattractant-induced cell migration",

abstract = "Cell migration refers to a directional cell movement in response to chemoattractant stimulation. In this work, we developed a cell-migration model by mimicking in vivo migration using optically manipulated chemoattractant-loaded microsources. The model facilitates a quantitative characterization of the relationship among the protrusion force, cell motility, and chemoattractant gradient for the first time (to our knowledge). We verified the correctness of the model using migrating leukemia cancer Jurkat cells. The results show that one can achieve the ideal migrating capacity by choosing the appropriate chemoattractant gradient and concentration at the leading edge of the cell.",

author = "Hao Yang and Xue Gou and Yong Wang and Fahmy, {Tarek M.} and Leung, {Anskar Y.-H.} and Jian Lu and Dong Sun",

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T1 - A dynamic model of chemoattractant-induced cell migration

AU - Yang, Hao

AU - Gou, Xue

AU - Wang, Yong

AU - Fahmy, Tarek M.

AU - Leung, Anskar Y.-H.

AU - Lu, Jian

AU - Sun, Dong

PY - 2015/4/7

Y1 - 2015/4/7

N2 - Cell migration refers to a directional cell movement in response to chemoattractant stimulation. In this work, we developed a cell-migration model by mimicking in vivo migration using optically manipulated chemoattractant-loaded microsources. The model facilitates a quantitative characterization of the relationship among the protrusion force, cell motility, and chemoattractant gradient for the first time (to our knowledge). We verified the correctness of the model using migrating leukemia cancer Jurkat cells. The results show that one can achieve the ideal migrating capacity by choosing the appropriate chemoattractant gradient and concentration at the leading edge of the cell.

AB - Cell migration refers to a directional cell movement in response to chemoattractant stimulation. In this work, we developed a cell-migration model by mimicking in vivo migration using optically manipulated chemoattractant-loaded microsources. The model facilitates a quantitative characterization of the relationship among the protrusion force, cell motility, and chemoattractant gradient for the first time (to our knowledge). We verified the correctness of the model using migrating leukemia cancer Jurkat cells. The results show that one can achieve the ideal migrating capacity by choosing the appropriate chemoattractant gradient and concentration at the leading edge of the cell.

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DO - 10.1016/j.bpj.2014.12.060

M3 - RGC 21 - Publication in refereed journal

C2 - 25863056

SN - 0006-3495

VL - 108

SP - 1645

EP - 1651

JO - Biophysical Journal

JF - Biophysical Journal

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A dynamic model of chemoattractant-induced cell migration

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GRF: Sensing, Modeling and Control of Cell Migration in Chemoattractant Environment Using a Robot-aided Cell Manipulation System Equipped with Optical Tweezers

CRF: Development of Cell Manipulation Tools for Probing Functional Mechanism of Hematopoietic Cells: Robotics, Optical tweezers, and Hematopoiesis

CRF: Development of Cell Manipulation Tools for Probing Functional Mechanism of Hematopoietic Cells: Robotics, Optical tweezers, and Hematopoiesis

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A dynamic model of chemoattractant-induced cell migration

Abstract

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Projects

GRF: Sensing, Modeling and Control of Cell Migration in Chemoattractant Environment Using a Robot-aided Cell Manipulation System Equipped with Optical Tweezers

CRF: Development of Cell Manipulation Tools for Probing Functional Mechanism of Hematopoietic Cells: Robotics, Optical tweezers, and Hematopoiesis

CRF: Development of Cell Manipulation Tools for Probing Functional Mechanism of Hematopoietic Cells: Robotics, Optical tweezers, and Hematopoiesis

Cite this