A dual organelle-targeting photosensitizer based on curcumin for enhanced photodynamic therapy

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

4 Scopus Citations
View graph of relations

Author(s)

  • Yanping Wang
  • Xuewei Li
  • Weimin Liu
  • Jie Sha
  • Zhe Yu
  • Shuai Wang
  • Haohui Ren
  • Pengfei Wang

Detail(s)

Original languageEnglish
Pages (from-to)10836-10844
Journal / PublicationJournal of Materials Chemistry B
Volume11
Issue number45
Online published26 Oct 2023
Publication statusPublished - 7 Dec 2023

Abstract

The efficiency of photodynamic therapy (PDT) is related to the subcellular localization of photosensitizers (PSs) because organelles are associated with many fundamental life-sustaining activities. In this work, we synthesized a PS (CN) based on curcumin (CUR) and obtained enhanced PDT efficiency by simultaneously targeting lipid droplets (LDs) and the endoplasmic reticulum (ER). Compared with CUR, CN with a D-π-A-π-D structure possessed stronger intramolecular charge transfer features, resulting in longer absorption and emission wavelengths. In cell imaging experiments of CN using a confocal laser scanning microscope, a bright green emission in LDs and a weak orange emission in the ER were simultaneously observed due to its sensitivity to polarity. Surprisingly, CN with low singlet oxygen yields (0.13) exhibited an excellent photodynamic effect. Further experimental results showed that the phototoxicity of CN resulted in apoptosis by destroying the ER and ferroptosis by oxidizing polyunsaturated fatty acids (PUFAs) in LDs. This work paves the way for developing more effective photosensitizers with superior dual-targeting specificity. © 2023 The Royal Society of Chemistry.

Citation Format(s)

A dual organelle-targeting photosensitizer based on curcumin for enhanced photodynamic therapy. / Wang, Yanping; Li, Xuewei; Liu, Weimin et al.
In: Journal of Materials Chemistry B, Vol. 11, No. 45, 07.12.2023, p. 10836-10844.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review