TY - JOUR
T1 - A Double-Layered Microneedle Platform Fabricated through Frozen Spray-Coating
AU - Ning, Xiaoyu
AU - Wiraja, Christian
AU - Lio, Daniel Chin Shiuan
AU - Xu, Chenjie
PY - 2020/5/20
Y1 - 2020/5/20
N2 - This work reports a frozen spray-coating method for the fabrication of double-layered microneedles (MNs). Taking swellable methacrylated hyaluronic acid (MeHA)-derived MNs as the model, both hydrophobic molecules (Nile red, Cy5) and hydrophilic ones (FITC, FITC-Dextran, Insulin) can be homogeneously coated without impacting the mechanical properties of the original MeHA MNs. The prepared double-layered MNs can execute multiple roles. It is demonstrated that insulin-coated MeHA double-layered MNs allow the effective delivery of the insulin into circulation of mice for controlling the blood glucose level while they also permit the extraction of skin interstitial fluid for the timely analysis of the biomarker (glucose).
AB - This work reports a frozen spray-coating method for the fabrication of double-layered microneedles (MNs). Taking swellable methacrylated hyaluronic acid (MeHA)-derived MNs as the model, both hydrophobic molecules (Nile red, Cy5) and hydrophilic ones (FITC, FITC-Dextran, Insulin) can be homogeneously coated without impacting the mechanical properties of the original MeHA MNs. The prepared double-layered MNs can execute multiple roles. It is demonstrated that insulin-coated MeHA double-layered MNs allow the effective delivery of the insulin into circulation of mice for controlling the blood glucose level while they also permit the extraction of skin interstitial fluid for the timely analysis of the biomarker (glucose).
KW - double-layered microneedles
KW - frozen spray-coating
KW - interstitial skin fluid extraction
KW - transdermal drug delivery
UR - http://www.scopus.com/inward/record.url?scp=85083843002&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85083843002&origin=recordpage
U2 - 10.1002/adhm.202000147
DO - 10.1002/adhm.202000147
M3 - RGC 21 - Publication in refereed journal
SN - 2192-2640
VL - 9
JO - Advanced Healthcare Materials
JF - Advanced Healthcare Materials
IS - 10
M1 - 2000147
ER -