A double branched photosensitive prodrug : Synthesis and characterization of light triggered drug release

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

3 Scopus Citations
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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)959-963
Journal / PublicationTetrahedron Letters
Volume57
Issue number8
Publication statusPublished - 24 Feb 2016

Abstract

A novel oNB based, double branched photosensitive prodrug 1, and a biphenyl counterpart 2 were designed and synthesized. Their photo-triggered drug release properties were studied by HPLC and UV-vis spectra. The isobestic points in UV-vis spectra of prodrug 1 indicated that homogeneous photolysis reaction happened upon xenon-based light irradiation. HPLC analysis confirmed that (antitumor) chlorambucil was released quickly accompanied with photobyproducts. Prodrug 1 has a half-time (t1/2) of 12.4 min, indicated a good sensitivity towards the light irradiation, making it a promising candidate for applications where UV light is limited.

Research Area(s)

  • Chlorambucil, Drug release, o-Nitrobenzyl, Photoremovable protecting group, Prodrug

Citation Format(s)

A double branched photosensitive prodrug : Synthesis and characterization of light triggered drug release. / Liu, Wei; Liang, Li; Lo, Pik Kwan; Gou, Xiao Jun; Sun, Xiao Hua.

In: Tetrahedron Letters, Vol. 57, No. 8, 24.02.2016, p. 959-963.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review