A double branched photosensitive prodrug : Synthesis and characterization of light triggered drug release
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
Author(s)
Detail(s)
| Original language | English |
|---|---|
| Pages (from-to) | 959-963 |
| Journal / Publication | Tetrahedron Letters |
| Volume | 57 |
| Issue number | 8 |
| Publication status | Published - 24 Feb 2016 |
Link(s)
Abstract
A novel oNB based, double branched photosensitive prodrug 1, and a biphenyl counterpart 2 were designed and synthesized. Their photo-triggered drug release properties were studied by HPLC and UV-vis spectra. The isobestic points in UV-vis spectra of prodrug 1 indicated that homogeneous photolysis reaction happened upon xenon-based light irradiation. HPLC analysis confirmed that (antitumor) chlorambucil was released quickly accompanied with photobyproducts. Prodrug 1 has a half-time (t1/2) of 12.4 min, indicated a good sensitivity towards the light irradiation, making it a promising candidate for applications where UV light is limited.
Research Area(s)
- Chlorambucil, Drug release, o-Nitrobenzyl, Photoremovable protecting group, Prodrug
Citation Format(s)
A double branched photosensitive prodrug : Synthesis and characterization of light triggered drug release. / Liu, Wei; Liang, Li; Lo, Pik Kwan; Gou, Xiao Jun; Sun, Xiao Hua.
In: Tetrahedron Letters, Vol. 57, No. 8, 24.02.2016, p. 959-963.Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
