A disinhibitory mechanism biases Drosophila innate light preference

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

5 Scopus Citations
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Author(s)

  • Weiqiao Zhao
  • Caixia Gong
  • Zhenhuan Ouyang
  • Jie Wang
  • Nenggan Zheng
  • Zhefeng Gong

Detail(s)

Original languageEnglish
Article number124
Journal / PublicationNature Communications
Volume10
Online published10 Jan 2019
Publication statusPublished - 2019
Externally publishedYes

Link(s)

Abstract

Innate preference toward environmental conditions is crucial for animal survival. Although much is known about the neural processing of sensory information, how the aversive or attractive sensory stimulus is transformed through central brain neurons into avoidance or approaching behavior is largely unclear. Here we show that Drosophila larval light preference behavior is regulated by a disinhibitory mechanism. In the disinhibitory circuit, a pair of GABAergic neurons exerts tonic inhibition on one pair of contralateral projecting neurons that control larval reorientation behavior. When a larva enters the light area, the reorientation-controlling neurons are disinhibited to allow reorientation to occur as the upstream inhibitory neurons are repressed by light. When the larva exits the light area, the inhibition on the downstream neurons is restored to repress further reorientation and thus prevents the larva from re-entering the light area. We suggest that disinhibition may serve as a common neural mechanism for animal innate preference behavior.

Research Area(s)

  • Animals, Animals, Genetically Modified, Avoidance Learning/physiology, Brain/cytology, Choice Behavior/physiology, Drosophila melanogaster/genetics, GABAergic Neurons/physiology, Larva/genetics, Light

Citation Format(s)

A disinhibitory mechanism biases Drosophila innate light preference. / Zhao, Weiqiao; Zhou, Peipei; Gong, Caixia; Ouyang, Zhenhuan; Wang, Jie; Zheng, Nenggan; Gong, Zhefeng.

In: Nature Communications, Vol. 10, 124, 2019.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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