A copper nanocluster incorporated nanogel : Confinement‐assisted emission enhancement for zinc ion detection in living cells

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Xueqing Gao
  • Xuming Zhuang
  • Chunyuan Tian
  • Huitao Liu
  • Wing-Fu Lai
  • Lingxin Chen

Detail(s)

Original languageEnglish
Article number127626
Journal / PublicationSensors and Actuators, B: Chemical
Volume307
Online published24 Dec 2019
Publication statusPublished - 15 Mar 2020

Abstract

In this work, copper nanoclusters (CuNCs), in which cysteine served as both a reducing agent and a protection ligand, were synthesized, and impregnated into a nanogel of glycol chitosan (GC), forming a CuNCs@GC nanocomposite. The stability of CuNCs incorporated into a nanogel was significantly improved, while their photoluminescence (PL) intensity of CuNCs@GC could be tuned by controlling the pH of the system. The nanocomposite was used as a platform for the “turn on” detection of Zn2+, making use of the effect of aggregation induced emission (AIE) enhancement. By adjusting the pH of the system to 7.4, the PL of CuNCs@GC was turned down so as to minimize the background signal. In the presence of Zn2+, the nanoclusters in CuNCs@GC changed from the dispersed state to the aggregated state, which resulted in an increase of the PL intensity. A linear response between the PL intensity and the concentration of Zn2+, in the range from 1.5 μM to 750 μM, was obtained, achieving a detection limit of 1.0 μM. Furthermore, the CuNCs@GC nanocomposite was found to be applicable to live cell imaging, owing to the high biocompatibility and protective effects of GC.

Research Area(s)

  • Aggregation induced emission, Cell imaging, Copper nanoclusters, Glycol chitosan, Zinc(II) detection

Citation Format(s)

A copper nanocluster incorporated nanogel : Confinement‐assisted emission enhancement for zinc ion detection in living cells. / Gao, Xueqing; Zhuang, Xuming; Tian, Chunyuan; Liu, Huitao; Lai, Wing-Fu; Wang, Zhenguang; Yang, Xuming; Chen, Lingxin; Rogach, Andrey L.

In: Sensors and Actuators, B: Chemical, Vol. 307, 127626, 15.03.2020.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal