A conjugative plasmid that augments virulence in Klebsiella pneumoniae

Xuemei Yang; Edward Wai-Chi  Chan; Rong Zhang; Sheng Chen

doi:10.1038/s41564-019-0566-7

Author(s)

Xuemei Yang
Edward Wai-Chi Chan
Rong Zhang
Sheng Chen

Related Research Unit(s)

Detail(s)

Original language	English
Pages (from-to)	2039–2043
Journal / Publication	Nature Microbiology
Volume	4
Issue number	12
Online published	30 Sep 2019
Publication status	Published - Dec 2019

Link(s)

DOI	DOI https://doi.org/10.1038/s41564-019-0566-7 Final Published version
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Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-85074328822&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(5224c2c6-079b-4229-afca-988e41da16b8).html

Abstract

A virulence-encoding plasmid, p15WZ-82_Vir, which formed as a result of the integration of a 100-kb fragment of the hypervirulence plasmid pLVPK into a conjugative IncFIB plasmid, was recovered from a clinical Klebsiella variicola strain. Such a plasmid could be conjugated to carbapenem-resistant Klebsiella strains, enabling them to simultaneously express the carbapenem resistance- and hypervirulence-associated phenotypes. Unlike the non-conjugative pLVPK plasmid, emergence of p15WZ-82_Vir may promote rapid dissemination of virulence-encoding elements among Gram-negative bacterial pathogens.

Citation Format(s)

[ RIS ] [ BibTeX ]

A conjugative plasmid that augments virulence in Klebsiella pneumoniae. / Yang, Xuemei; Chan, Edward Wai-Chi ; Zhang, Rong; Chen, Sheng.

In: Nature Microbiology, Vol. 4, No. 12, 12.2019, p. 2039–2043.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

Yang, X, Chan, EW-C, Zhang, R & Chen, S 2019, 'A conjugative plasmid that augments virulence in Klebsiella pneumoniae', Nature Microbiology, vol. 4, no. 12, pp. 2039–2043. https://doi.org/10.1038/s41564-019-0566-7

Yang, X., Chan, E. W-C., Zhang, R., & Chen, S. (2019). A conjugative plasmid that augments virulence in Klebsiella pneumoniae. Nature Microbiology, 4(12), 2039–2043. https://doi.org/10.1038/s41564-019-0566-7

Yang X, Chan EW-C, Zhang R, Chen S. A conjugative plasmid that augments virulence in Klebsiella pneumoniae. Nature Microbiology. 2019 Dec;4(12):2039–2043. https://doi.org/10.1038/s41564-019-0566-7

Yang, Xuemei ; Chan, Edward Wai-Chi ; Zhang, Rong ; Chen, Sheng. / A conjugative plasmid that augments virulence in Klebsiella pneumoniae. In: Nature Microbiology. 2019 ; Vol. 4, No. 12. pp. 2039–2043.