A conjugative plasmid that augments virulence in Klebsiella pneumoniae
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
Author(s)
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Detail(s)
Original language | English |
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Pages (from-to) | 2039–2043 |
Journal / Publication | Nature Microbiology |
Volume | 4 |
Issue number | 12 |
Online published | 30 Sep 2019 |
Publication status | Published - Dec 2019 |
Link(s)
Abstract
A virulence-encoding plasmid, p15WZ-82_Vir, which formed as a result of the integration of a 100-kb fragment of the hypervirulence plasmid pLVPK into a conjugative IncFIB plasmid, was recovered from a clinical Klebsiella variicola strain. Such a plasmid could be conjugated to carbapenem-resistant Klebsiella strains, enabling them to simultaneously express the carbapenem resistance- and hypervirulence-associated phenotypes. Unlike the non-conjugative pLVPK plasmid, emergence of p15WZ-82_Vir may promote rapid dissemination of virulence-encoding elements among Gram-negative bacterial pathogens.
Citation Format(s)
A conjugative plasmid that augments virulence in Klebsiella pneumoniae. / Yang, Xuemei; Chan, Edward Wai-Chi ; Zhang, Rong; Chen, Sheng.
In: Nature Microbiology, Vol. 4, No. 12, 12.2019, p. 2039–2043.Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review