A conjugative plasmid that augments virulence in Klebsiella pneumoniae

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

13 Scopus Citations
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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)2039–2043
Journal / PublicationNature Microbiology
Volume4
Issue number12
Online published30 Sep 2019
Publication statusPublished - Dec 2019

Abstract

A virulence-encoding plasmid, p15WZ-82_Vir, which formed as a result of the integration of a 100-kb fragment of the hypervirulence plasmid pLVPK into a conjugative IncFIB plasmid, was recovered from a clinical Klebsiella variicola strain. Such a plasmid could be conjugated to carbapenem-resistant Klebsiella strains, enabling them to simultaneously express the carbapenem resistance- and hypervirulence-associated phenotypes. Unlike the non-conjugative pLVPK plasmid, emergence of p15WZ-82_Vir may promote rapid dissemination of virulence-encoding elements among Gram-negative bacterial pathogens.

Citation Format(s)

A conjugative plasmid that augments virulence in Klebsiella pneumoniae. / Yang, Xuemei; Chan, Edward Wai-Chi ; Zhang, Rong; Chen, Sheng.

In: Nature Microbiology, Vol. 4, No. 12, 12.2019, p. 2039–2043.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal