A conjugative plasmid that augments virulence in Klebsiella pneumoniae

Xuemei Yang; Edward Wai-Chi  Chan; Rong Zhang; Sheng Chen

doi:10.1038/s41564-019-0566-7

A conjugative plasmid that augments virulence in Klebsiella pneumoniae

Xuemei Yang
, Edward Wai-Chi Chan
, Rong Zhang
, Sheng Chen^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

135 Citations (Scopus)

Abstract

A virulence-encoding plasmid, p15WZ-82_Vir, which formed as a result of the integration of a 100-kb fragment of the hypervirulence plasmid pLVPK into a conjugative IncFIB plasmid, was recovered from a clinical Klebsiella variicola strain. Such a plasmid could be conjugated to carbapenem-resistant Klebsiella strains, enabling them to simultaneously express the carbapenem resistance- and hypervirulence-associated phenotypes. Unlike the non-conjugative pLVPK plasmid, emergence of p15WZ-82_Vir may promote rapid dissemination of virulence-encoding elements among Gram-negative bacterial pathogens.

Original language	English
Pages (from-to)	2039–2043
Journal	Nature Microbiology
Volume	4
Issue number	12
Online published	30 Sept 2019
DOIs	https://doi.org/10.1038/s41564-019-0566-7
Publication status	Published - Dec 2019

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title = "A conjugative plasmid that augments virulence in Klebsiella pneumoniae",

abstract = "A virulence-encoding plasmid, p15WZ-82\_Vir, which formed as a result of the integration of a 100-kb fragment of the hypervirulence plasmid pLVPK into a conjugative IncFIB plasmid, was recovered from a clinical Klebsiella variicola strain. Such a plasmid could be conjugated to carbapenem-resistant Klebsiella strains, enabling them to simultaneously express the carbapenem resistance- and hypervirulence-associated phenotypes. Unlike the non-conjugative pLVPK plasmid, emergence of p15WZ-82\_Vir may promote rapid dissemination of virulence-encoding elements among Gram-negative bacterial pathogens.",

author = "Xuemei Yang and Chan, \{Edward Wai-Chi\} and Rong Zhang and Sheng Chen",

year = "2019",

month = dec,

doi = "10.1038/s41564-019-0566-7",

language = "English",

volume = "4",

pages = "2039–2043",

journal = "Nature Microbiology",

issn = "2058-5276",

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TY - JOUR

T1 - A conjugative plasmid that augments virulence in Klebsiella pneumoniae

AU - Yang, Xuemei

AU - Chan, Edward Wai-Chi

AU - Zhang, Rong

AU - Chen, Sheng

PY - 2019/12

Y1 - 2019/12

N2 - A virulence-encoding plasmid, p15WZ-82_Vir, which formed as a result of the integration of a 100-kb fragment of the hypervirulence plasmid pLVPK into a conjugative IncFIB plasmid, was recovered from a clinical Klebsiella variicola strain. Such a plasmid could be conjugated to carbapenem-resistant Klebsiella strains, enabling them to simultaneously express the carbapenem resistance- and hypervirulence-associated phenotypes. Unlike the non-conjugative pLVPK plasmid, emergence of p15WZ-82_Vir may promote rapid dissemination of virulence-encoding elements among Gram-negative bacterial pathogens.

AB - A virulence-encoding plasmid, p15WZ-82_Vir, which formed as a result of the integration of a 100-kb fragment of the hypervirulence plasmid pLVPK into a conjugative IncFIB plasmid, was recovered from a clinical Klebsiella variicola strain. Such a plasmid could be conjugated to carbapenem-resistant Klebsiella strains, enabling them to simultaneously express the carbapenem resistance- and hypervirulence-associated phenotypes. Unlike the non-conjugative pLVPK plasmid, emergence of p15WZ-82_Vir may promote rapid dissemination of virulence-encoding elements among Gram-negative bacterial pathogens.

UR - https://www.scopus.com/pages/publications/85074328822

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85074328822&origin=recordpage

U2 - 10.1038/s41564-019-0566-7

DO - 10.1038/s41564-019-0566-7

M3 - RGC 21 - Publication in refereed journal

SN - 2058-5276

VL - 4

SP - 2039

EP - 2043

JO - Nature Microbiology

JF - Nature Microbiology

IS - 12

ER -

A conjugative plasmid that augments virulence in Klebsiella pneumoniae

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Researchers discover conjugative plasmid that augments virulence in superbug

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A conjugative plasmid that augments virulence in Klebsiella pneumoniae

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Researchers discover conjugative plasmid that augments virulence in superbug

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