A Conjugative IncI1 Plasmid Carrying erm(B) and blaCTX-M-104 That Mediates Resistance to Azithromycin and Cephalosporins

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

3 Scopus Citations
View graph of relations

Author(s)

Detail(s)

Original languageEnglish
Article numbere00286-21
Journal / PublicationMicrobiology Spectrum
Volume9
Issue number2
Online published8 Sept 2021
Publication statusPublished - Oct 2021

Link(s)

Abstract

In this study, an IncI1 plasmid encoding resistance to both cefotaxime and azithromycin was recovered from a clinical Klebsiella pneumoniae strain. The azithromycin resistance was confirmed to be mediated by the erm(B) gene. This plasmid could be readily conjugated to strains of Escherichia coli and Salmonella, promoting rapid dissemination of azithromycin- and ceftriaxone-resistance-encoding elements among Gram-negative bacterial pathogens. Transmission of this plasmid in Salmonella is of particular concern, since it could mediate expression of phenotypic resistance to azithromycin and ceftriaxone, which are the current choices for treatment of Salmonella infections. Our findings suggest a need to monitor the efficiency and pattern of transmission of this plasmid among key Gram-negative bacterial pathogens.

Research Area(s)

  • Klebsiella pneumoniae, azithromycin resistance, colistin resistance, erm(B), mcr-8

Citation Format(s)

A Conjugative IncI1 Plasmid Carrying erm(B) and blaCTX-M-104 That Mediates Resistance to Azithromycin and Cephalosporins. / Yang, Xuemei; Liu, Xiaoxuan; Yang, Chen et al.
In: Microbiology Spectrum, Vol. 9, No. 2, e00286-21, 10.2021.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

Download Statistics

No data available