A Concerted Enzymatic and Bioorthogonal Approach for Extra- and Intracellular Activation of Environment-Sensitive Ruthenium(II)-Based Imaging Probes and Photosensitizers
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Author(s)
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Detail(s)
Original language | English |
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Article number | e202303931 |
Journal / Publication | Angewandte Chemie (International Edition) |
Volume | 62 |
Issue number | 29 |
Online published | 16 May 2023 |
Publication status | Published - 17 Jul 2023 |
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DOI | DOI |
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Attachment(s) | Documents
Publisher's Copyright Statement
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Link to Scopus | https://www.scopus.com/record/display.uri?eid=2-s2.0-85161668489&origin=recordpage |
Permanent Link | https://scholars.cityu.edu.hk/en/publications/publication(aec1dd93-f5d5-42f5-8141-c9fa46dda099).html |
Abstract
In this article, we report a novel targeting strategy involving the combination of an enzyme-instructed self-assembly (EISA) moiety and a strained cycloalkyne to generate large accumulation of bioorthogonal sites in cancer cells. These bioorthogonal sites can serve as activation triggers in different regions for transition metal-based probes, which are new ruthenium(II) complexes carrying a tetrazine unit for controllable phosphorescence and singlet oxygen generation. Importantly, the environment-sensitive emission of the complexes can be further enhanced in the hydrophobic regions offered by the large supramolecular assemblies, which is highly advantageous to biological imaging. Additionally, the (photo)cytotoxicity of the large supramolecular assemblies containing the complexes was investigated, and the results illustrate that cellular localization (extracellular and intracellular) imposes a profound impact on the efficiencies of photosensitizers.
Research Area(s)
- Bioorthogonal, Enzyme-Instructed Self-Assembly, Imaging Agents, Photosensitizers, Ruthenium, TRANSITION-METAL-COMPLEXES, ALKALINE-PHOSPHATASES, PHOTODYNAMIC THERAPY, PROSTATE-CANCER, SINGLET OXYGEN, MEMBRANE, EMISSION, DESIGN, CELLS, RAFTS
Citation Format(s)
A Concerted Enzymatic and Bioorthogonal Approach for Extra- and Intracellular Activation of Environment-Sensitive Ruthenium(II)-Based Imaging Probes and Photosensitizers. / Shum, Justin; Lee, Lawrence Cho-Cheung; Chiang, Michael Wai-Lun et al.
In: Angewandte Chemie (International Edition), Vol. 62, No. 29, e202303931, 17.07.2023.
In: Angewandte Chemie (International Edition), Vol. 62, No. 29, e202303931, 17.07.2023.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
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