A combination of serum iron, ferritin and transferrin predicts outcome in patients with intracerebral hemorrhage

Guang Yang; Rong Hu; Chao Zhang; Christopher Qian; Qian-Qian Luo; Wing-Ho Yung; Ya Ke; Hua Feng; Zhong-Ming Qian

doi:10.1038/srep21970

A combination of serum iron, ferritin and transferrin predicts outcome in patients with intracerebral hemorrhage

Guang Yang, Rong Hu, Chao Zhang, Christopher Qian, Qian-Qian Luo, Wing-Ho Yung, Ya Ke^*, Hua Feng, Zhong-Ming Qian

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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Abstract

Association of a high-serum ferritin with poor outcome showed that iron might play a detrimental role in the brain after intracerebral hemorrhage (ICH). Here, we investigated changes in serum iron, ferritin, transferrin (Tf) and ceruloplasmin (CP) in patients with ICH (n = 100) at day 1 (admission), 3, 7, 14 and 21 and those in control subjects (n = 75). The hematoma and edema volumes were also determined in ICH-patients on admission and at day 3. The Modified Rankin Scale (mRS) of 59 patients was ≥3 (poor outcome) and 41 < 3 (good outcome) at day 90. Serum ferritin was significantly higher and serum iron and Tf markedly lower in patients with poor-outcome than the corresponding values in patients with good-outcome at day 1 to 7 and those in the controls. There was a significant positive correlation between serum ferritin and relative edema volume or ratio at day 1 and 3 and hematoma volume at day 1 (n = 28), and a negative correlation between serum iron or Tf and hematoma volume at day 1 (n = 100). We concluded that not only increased serum ferritin but also reduced serum iron and Tf are associated with outcome as well as hematoma volume. © 2016, Nature Publishing Group. All rights reserved.

Original language	English
Article number	21970
Journal	Scientific Reports
Volume	6
DOIs	https://doi.org/10.1038/srep21970
Publication status	Published - 22 Feb 2016
Externally published	Yes

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Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Funding

The studies in our laboratories were supported by the Key Project Grant of National Natural Science Foundation of China (31330035), General Grant of National Natural Science Foundation of China (31271132, 31371092, 31571195), Hong Kong Health and Medical Research Fund (01120146), the Competitive Earmarked Grants of The Hong Kong Research Grants Council (GRF14106914, GRF14111815), and National 973 Programs (2014CB541604).

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abstract = "Association of a high-serum ferritin with poor outcome showed that iron might play a detrimental role in the brain after intracerebral hemorrhage (ICH). Here, we investigated changes in serum iron, ferritin, transferrin (Tf) and ceruloplasmin (CP) in patients with ICH (n = 100) at day 1 (admission), 3, 7, 14 and 21 and those in control subjects (n = 75). The hematoma and edema volumes were also determined in ICH-patients on admission and at day 3. The Modified Rankin Scale (mRS) of 59 patients was ≥3 (poor outcome) and 41 < 3 (good outcome) at day 90. Serum ferritin was significantly higher and serum iron and Tf markedly lower in patients with poor-outcome than the corresponding values in patients with good-outcome at day 1 to 7 and those in the controls. There was a significant positive correlation between serum ferritin and relative edema volume or ratio at day 1 and 3 and hematoma volume at day 1 (n = 28), and a negative correlation between serum iron or Tf and hematoma volume at day 1 (n = 100). We concluded that not only increased serum ferritin but also reduced serum iron and Tf are associated with outcome as well as hematoma volume. {\textcopyright} 2016, Nature Publishing Group. All rights reserved.",

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A combination of serum iron, ferritin and transferrin predicts outcome in patients with intracerebral hemorrhage

Abstract

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