A chromo- and fluorogenic sensor for probing the cancer biomarker lysophosphatidic acid

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

6 Scopus Citations
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Author(s)

  • Wenwen Zhao
  • Weimin Liu
  • Lintao Zeng
  • Zhiyuan Fan
  • Jiasheng Wu
  • Pengfei Wang

Detail(s)

Original languageEnglish
Pages (from-to)1853-1859
Journal / PublicationAnalyst
Volume137
Issue number8
Publication statusPublished - 21 Apr 2012

Abstract

A novel chromo- and fluorogenic sensor, 4-(4-dimethylaminostyryl)-1- hexadecylpyridinium (DSHP) for lysophosphatidic acid (LPA) was successfully developed by incorporating a long alkyl chain into the cyanine molecule. DSHP shows excellent selectivity and high sensitivity towards LPA with a detection limit of about 7.09 × 10 -7 M based on electrostatic and hydrophobic interactions between the sensor and LPA. Upon addition of LPA ranging from 0 to 7.5 × 10 -4 M, DSHP displays an 'on-off-on' fluorescence response and obvious colour change. Good linear relationships between the fluorescence intensity and LPA concentrations were achieved in the fluorescence quenching ranges of 0-28 μM and 34-52 μM, which could be attributed to the combined effects of the photoinduced electron transfer and LPA-induced aggregation of the sensor molecules. © 2012 The Royal Society of Chemistry.

Citation Format(s)

A chromo- and fluorogenic sensor for probing the cancer biomarker lysophosphatidic acid. / Zhao, Wenwen; Liu, Weimin; Zhang, Wenjun; Zeng, Lintao; Fan, Zhiyuan; Wu, Jiasheng; Wang, Pengfei.

In: Analyst, Vol. 137, No. 8, 21.04.2012, p. 1853-1859.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal