TY - JOUR
T1 - A Blood-Resistant Surgical Glue for Minimally Invasive Repair of Vessels and Heart Defects
AU - Lang, Nora
AU - Pereira, Maria J.
AU - Lee, Yuhan
AU - Friehs, Ingeborg
AU - Vasilyev, Nikolay V.
AU - Feins, Eric N.
AU - Ablasser, Klemens
AU - O'Cearbhaill, Eoin D.
AU - Xu, Chenjie
AU - Fabozzo, Assunta
AU - Padera, Robert
AU - Wasserman, Steve
AU - Freudenthal, Franz
AU - Ferreira, Lino S.
AU - Langer, Robert
AU - Karp, Jeffrey M.
AU - del Nido, Pedro J.
PY - 2014/1/8
Y1 - 2014/1/8
N2 - Currently, there are no clinically approved surgical glues that are nontoxic, bind strongly to tissue, and work well withinwet and highly dynamic environments within the body. This is especially relevant tominimally invasive surgery that is increasingly performed to reduce postoperative complications, recovery times, and patient discomfort. We describe the engineering of a bioinspired elastic and biocompatible hydrophobic light-activated adhesive (HLAA) that achieves a strong level of adhesion to wet tissue and is not compromised by preexposure to blood. The HLAA provided an on-demand hemostatic seal, within seconds of light application, when applied to high-pressure large blood vessels and cardiac wall defects in pigs. HLAA-coated patches attached to the interventricular septum in a beating porcine heart and resisted supraphysiologic pressures by remaining attached for 24 hours, which is relevant to intracardiac interventions in humans. The HLAA could be used for many cardiovascular and surgical applications, with immediate application in repair of vascular defects and surgical hemostasis.
AB - Currently, there are no clinically approved surgical glues that are nontoxic, bind strongly to tissue, and work well withinwet and highly dynamic environments within the body. This is especially relevant tominimally invasive surgery that is increasingly performed to reduce postoperative complications, recovery times, and patient discomfort. We describe the engineering of a bioinspired elastic and biocompatible hydrophobic light-activated adhesive (HLAA) that achieves a strong level of adhesion to wet tissue and is not compromised by preexposure to blood. The HLAA provided an on-demand hemostatic seal, within seconds of light application, when applied to high-pressure large blood vessels and cardiac wall defects in pigs. HLAA-coated patches attached to the interventricular septum in a beating porcine heart and resisted supraphysiologic pressures by remaining attached for 24 hours, which is relevant to intracardiac interventions in humans. The HLAA could be used for many cardiovascular and surgical applications, with immediate application in repair of vascular defects and surgical hemostasis.
UR - http://www.scopus.com/inward/record.url?scp=84892553926&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-84892553926&origin=recordpage
U2 - 10.1126/scitranslmed.3006557
DO - 10.1126/scitranslmed.3006557
M3 - RGC 21 - Publication in refereed journal
C2 - 24401941
SN - 1946-6234
VL - 6
JO - Science Translational Medicine
JF - Science Translational Medicine
IS - 218
M1 - 218ra6
ER -