A 3D printable tissue adhesive

Sarah J. Wu; Jingjing Wu; Samuel J. Kaser; Heejung Roh; Ruth D. Shiferaw; Hyunwoo Yuk; Xuanhe Zhao

doi:10.1038/s41467-024-45147-9

A 3D printable tissue adhesive

Sarah J. Wu
, Jingjing Wu
, Samuel J. Kaser
, Heejung Roh
, Ruth D. Shiferaw
, Hyunwoo Yuk^*
, Xuanhe Zhao^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

76 Citations (Scopus)

Abstract

Tissue adhesives are promising alternatives to sutures and staples for joining tissues, sealing defects, and immobilizing devices. However, existing adhesives mostly take the forms of glues or hydrogels, which offer limited versatility. We report a direct-ink-write 3D printable tissue adhesive which can be used to fabricate bioadhesive patches and devices with programmable architectures, unlocking new potential for application-specific designs. The adhesive is conformable and stretchable, achieves robust adhesion with wet tissues within seconds, and exhibits favorable biocompatibility. In vivo rat trachea and colon defect models demonstrate the fluid-tight tissue sealing capability of the printed patches, which maintained adhesion over 4 weeks. Moreover, incorporation of a blood-repelling hydrophobic matrix enables the printed patches to seal actively bleeding tissues. Beyond wound closure, the 3D printable adhesive has broad applicability across various tissue-interfacing devices, highlighted through representative proof-of-concept designs. Together, this platform offers a promising strategy toward developing advanced tissue adhesive technologies. © The Author(s) 2024.

Original language	English
Article number	1215
Number of pages	12
Journal	Nature Communications
Volume	15
Online published	9 Feb 2024
DOIs	https://doi.org/10.1038/s41467-024-45147-9
Publication status	Published - 2024
Externally published	Yes

Funding

The authors thank the Koch Institute Swanson Biotechnology Center for technical support with animal studies and the Histology Core for histological processing. The authors also thank Dr. Raphael Bueno and Dr. Robert F. Padera at Brigham and Women's Hospital for helpful discussions and histological feedback. This work is supported by the National Institutes of Health (no. 1R01HL153857-01 and No. 1R01HL167947-01, X.Z.), the National Science Foundation (Grant No. EFMA-1935291, X.Z.), and Department of Defense Congressionally Directed Medical Research Programs (Grant No. PR200524P1, X.Z.). S.W. acknowledges financial support from the National Science Foundation (NSF) Graduate Research Fellowship Program.

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This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/

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title = "A 3D printable tissue adhesive",

abstract = "Tissue adhesives are promising alternatives to sutures and staples for joining tissues, sealing defects, and immobilizing devices. However, existing adhesives mostly take the forms of glues or hydrogels, which offer limited versatility. We report a direct-ink-write 3D printable tissue adhesive which can be used to fabricate bioadhesive patches and devices with programmable architectures, unlocking new potential for application-specific designs. The adhesive is conformable and stretchable, achieves robust adhesion with wet tissues within seconds, and exhibits favorable biocompatibility. In vivo rat trachea and colon defect models demonstrate the fluid-tight tissue sealing capability of the printed patches, which maintained adhesion over 4 weeks. Moreover, incorporation of a blood-repelling hydrophobic matrix enables the printed patches to seal actively bleeding tissues. Beyond wound closure, the 3D printable adhesive has broad applicability across various tissue-interfacing devices, highlighted through representative proof-of-concept designs. Together, this platform offers a promising strategy toward developing advanced tissue adhesive technologies. {\textcopyright} The Author(s) 2024.",

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AU - Shiferaw, Ruth D.

AU - Yuk, Hyunwoo

AU - Zhao, Xuanhe

PY - 2024

Y1 - 2024

N2 - Tissue adhesives are promising alternatives to sutures and staples for joining tissues, sealing defects, and immobilizing devices. However, existing adhesives mostly take the forms of glues or hydrogels, which offer limited versatility. We report a direct-ink-write 3D printable tissue adhesive which can be used to fabricate bioadhesive patches and devices with programmable architectures, unlocking new potential for application-specific designs. The adhesive is conformable and stretchable, achieves robust adhesion with wet tissues within seconds, and exhibits favorable biocompatibility. In vivo rat trachea and colon defect models demonstrate the fluid-tight tissue sealing capability of the printed patches, which maintained adhesion over 4 weeks. Moreover, incorporation of a blood-repelling hydrophobic matrix enables the printed patches to seal actively bleeding tissues. Beyond wound closure, the 3D printable adhesive has broad applicability across various tissue-interfacing devices, highlighted through representative proof-of-concept designs. Together, this platform offers a promising strategy toward developing advanced tissue adhesive technologies. © The Author(s) 2024.

AB - Tissue adhesives are promising alternatives to sutures and staples for joining tissues, sealing defects, and immobilizing devices. However, existing adhesives mostly take the forms of glues or hydrogels, which offer limited versatility. We report a direct-ink-write 3D printable tissue adhesive which can be used to fabricate bioadhesive patches and devices with programmable architectures, unlocking new potential for application-specific designs. The adhesive is conformable and stretchable, achieves robust adhesion with wet tissues within seconds, and exhibits favorable biocompatibility. In vivo rat trachea and colon defect models demonstrate the fluid-tight tissue sealing capability of the printed patches, which maintained adhesion over 4 weeks. Moreover, incorporation of a blood-repelling hydrophobic matrix enables the printed patches to seal actively bleeding tissues. Beyond wound closure, the 3D printable adhesive has broad applicability across various tissue-interfacing devices, highlighted through representative proof-of-concept designs. Together, this platform offers a promising strategy toward developing advanced tissue adhesive technologies. © The Author(s) 2024.

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A 3D printable tissue adhesive

Abstract

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