Abstract
We developed an in vitro Platform to investigate how intratumoral bacteria (IB) and extratumoral bacteria (EB) (PIEB) affect tumor progression. Pathogen-cancer cell co-culture models were established to mimic the infecting and colonization states of bacteria in the cancer microenvironment. Based on this microwell-based microfluidic chip, various in situ downstream assays of tumor cell clusters can be applied, and the cancer-protecting effects of extracellular biofilms formed by EB were proved to have protective effects on cancer cells. We further proposed a combinational triple-drug therapy, which could destroy the biofilm structure and kill cancer cells simultaneously to achieve an effective treatment effect.
| Original language | English |
|---|---|
| Title of host publication | MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 79-80 |
| ISBN (Print) | 978-1-7334190-3-1 |
| Publication status | Published - Oct 2021 |
| Event | 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2021) - Hybrid, Palm Springs, United States Duration: 10 Oct 2021 → 14 Oct 2021 https://microtas2021.org https://www.cbmsociety.org/conference/proceedings_archive.html http://www.microtas2021.org |
Publication series
| Name | MicroTAS - International Conference on Miniaturized Systems for Chemistry and Life Sciences |
|---|
Conference
| Conference | 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2021) |
|---|---|
| Abbreviated title | MicroTAS 2021 |
| Country/Territory | United States |
| City | Palm Springs |
| Period | 10/10/21 → 14/10/21 |
| Internet address |
Research Keywords
- biofilms
- combinational cancer therapy
- Microfluidics
- tumor models
