3D Upconversion Barcodes for Combinatory Wireless Neuromodulation in Behaving Animals

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

View graph of relations

Author(s)

  • Xudong Lin
  • Minghui Tang
  • Anqi Yang
  • Richard Yan-Do
  • Yaobin Gao
  • Xin Duan

Detail(s)

Original languageEnglish
Article number2200304
Journal / PublicationAdvanced Healthcare Materials
Volume11
Issue number13
Online published15 Apr 2022
Publication statusPublished - 6 Jul 2022

Abstract

Upconversion techniques offer all-optical wireless alternatives to modulate targeted neurons in behaving animals, but most existing upconversion-based optogenetic devices show prefixed emission that is used to excite just one channelrhodopsin at a restricted brain region. Here, a hierarchical upconversion device is reported to enable spatially selective and combinatory optogenetics in behaving rodent animals. The device assumes a multiarrayed optrode format containing engineered upconversion nanoparticles (UCNPs) to deliver dynamic light palettes as a function of excitation wavelength. Three primary emissions at 477, 540, and 654 nm are selected to match the absorption of different channelrhodopsins. The UCNPs are barcode assembled to multiple nanomachined optical pinholes in a microscale pipette device to allow remotely addressable, spectrum programmable, and spatially selective optical interrogation of complex brain circuits. Using the unique device, the basolateral amygdala and caudoputamen circuits are selectively modulated and the associated fear or anxiety behavior in freely behaving rodents is successfully differentiated. It is believed that the 3D barcode upconversion device would be a great supplement to current optogenetic toolsets and opens up new possibilities for sophisticated neural control.

Research Area(s)

  • neural interfaces, remote neuromodulation, selective brain stimulation, upconversion nanoparticles, wireless optogenetics, VIVO PHOTODYNAMIC THERAPY, LIGHT DELIVERY, NANOPARTICLES, CIRCUITS, AMYGDALA, FEAR, OPTOGENETICS, STIMULATION, EMISSION, MEMORY

Citation Format(s)

3D Upconversion Barcodes for Combinatory Wireless Neuromodulation in Behaving Animals. / Lin, Xudong; Sun, Tianying; Tang, Minghui; Yang, Anqi; Yan-Do, Richard; Chen, Da; Gao, Yaobin; Duan, Xin; Kai, Ji-Jung; Wang, Feng; Shi, Peng.

In: Advanced Healthcare Materials, Vol. 11, No. 13, 2200304, 06.07.2022.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review