3D printing of tissue-simulating phantoms for calibration of biomedical optical devices

Zuhua Zhao; Ximing Zhou; Shuwei Shen; Guangli Liu; Li Yuan; Yuquan Meng; Xiang Lv; Pengfei Shao; Erbao Dong; Ronald X. Xu

doi:10.1117/12.2246273

3D printing of tissue-simulating phantoms for calibration of biomedical optical devices

Zuhua Zhao
, Ximing Zhou
, Shuwei Shen
, Guangli Liu
, Li Yuan
, Yuquan Meng
, Xiang Lv
, Pengfei Shao
, Erbao Dong
, Ronald X. Xu

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

7 Citations (Scopus)

Abstract

Clinical utility of many biomedical optical devices is limited by the lack of effective and traceable calibration methods. Optical phantoms that simulate biological tissues used for optical device calibration have been explored. However, these phantoms can hardly simulate both structural and optical properties of multi-layered biological tissue. To address this limitation, we develop a 3D printing production line that integrates spin coating, light-cured 3D printing and Fused Deposition Modeling (FDM) for freeform fabrication of optical phantoms with mechanical and optical heterogeneities. With the gel wax Polydimethylsiloxane (PDMS), and colorless light-curable ink as matrix materials, titanium dioxide (TiO₂) powder as the scattering ingredient, graphite powder and black carbon as the absorption ingredient, a multilayer phantom with high-precision is fabricated. The absorption and scattering coefficients of each layer are measured by a double integrating sphere system. The results demonstrate that the system has the potential to fabricate reliable tissue-simulating phantoms to calibrate optical imaging devices. © 2016 SPIE.

Original language	English
Title of host publication	Optics in Health Care and Biomedical Optics VII
Publisher	SPIE - International Society for Optical Engineering
Volume	10024
ISBN (Print)	9781510604674
DOIs	https://doi.org/10.1117/12.2246273
Publication status	Published - 2016
Externally published	Yes
Event	Optics in Health Care and Biomedical Optics VII - Beijing, China Duration: 12 Oct 2016 → 14 Oct 2016

Publication series

Name	Proceedings of SPIE - The International Society for Optical Engineering
Volume	10024
ISSN (Print)	0277-786X
ISSN (Electronic)	1996-756X

Conference

Conference	Optics in Health Care and Biomedical Optics VII
Place	China
City	Beijing
Period	12/10/16 → 14/10/16

Bibliographical note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 9 Industry, Innovation, and Infrastructure

Research Keywords

absorption
FDM
light-cured 3D printing
scattering.
spin coating
tissue optical phantom

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10.1117/12.2246273

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Cite this

Zhao, Z., Zhou, X., Shen, S., Liu, G., Yuan, L., Meng, Y., Lv, X., Shao, P., Dong, E., & Xu, R. X. (2016). 3D printing of tissue-simulating phantoms for calibration of biomedical optical devices. In Optics in Health Care and Biomedical Optics VII (Vol. 10024). Article 100240N (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 10024). SPIE - International Society for Optical Engineering. https://doi.org/10.1117/12.2246273

@inproceedings{e8b3d9ae473642f7868ae8dd7d8ebed5,

title = "3D printing of tissue-simulating phantoms for calibration of biomedical optical devices",

abstract = "Clinical utility of many biomedical optical devices is limited by the lack of effective and traceable calibration methods. Optical phantoms that simulate biological tissues used for optical device calibration have been explored. However, these phantoms can hardly simulate both structural and optical properties of multi-layered biological tissue. To address this limitation, we develop a 3D printing production line that integrates spin coating, light-cured 3D printing and Fused Deposition Modeling (FDM) for freeform fabrication of optical phantoms with mechanical and optical heterogeneities. With the gel wax Polydimethylsiloxane (PDMS), and colorless light-curable ink as matrix materials, titanium dioxide (TiO2) powder as the scattering ingredient, graphite powder and black carbon as the absorption ingredient, a multilayer phantom with high-precision is fabricated. The absorption and scattering coefficients of each layer are measured by a double integrating sphere system. The results demonstrate that the system has the potential to fabricate reliable tissue-simulating phantoms to calibrate optical imaging devices. {\textcopyright} 2016 SPIE.",

keywords = "absorption, FDM, light-cured 3D printing, scattering., spin coating, tissue optical phantom",

author = "Zuhua Zhao and Ximing Zhou and Shuwei Shen and Guangli Liu and Li Yuan and Yuquan Meng and Xiang Lv and Pengfei Shao and Erbao Dong and Xu, \{Ronald X.\}",

note = "Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].; Optics in Health Care and Biomedical Optics VII ; Conference date: 12-10-2016 Through 14-10-2016",

year = "2016",

doi = "10.1117/12.2246273",

language = "English",

isbn = "9781510604674",

volume = "10024",

series = "Proceedings of SPIE - The International Society for Optical Engineering",

publisher = "SPIE - International Society for Optical Engineering",

booktitle = "Optics in Health Care and Biomedical Optics VII",

address = "United States",

}

Zhao, Z, Zhou, X, Shen, S, Liu, G, Yuan, L, Meng, Y, Lv, X, Shao, P, Dong, E & Xu, RX 2016, 3D printing of tissue-simulating phantoms for calibration of biomedical optical devices. in Optics in Health Care and Biomedical Optics VII. vol. 10024, 100240N, Proceedings of SPIE - The International Society for Optical Engineering, vol. 10024, SPIE - International Society for Optical Engineering, Optics in Health Care and Biomedical Optics VII, Beijing, China, 12/10/16. https://doi.org/10.1117/12.2246273

3D printing of tissue-simulating phantoms for calibration of biomedical optical devices. / Zhao, Zuhua; Zhou, Ximing; Shen, Shuwei et al.
Optics in Health Care and Biomedical Optics VII. Vol. 10024 SPIE - International Society for Optical Engineering, 2016. 100240N (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 10024).

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

TY - GEN

T1 - 3D printing of tissue-simulating phantoms for calibration of biomedical optical devices

AU - Zhao, Zuhua

AU - Zhou, Ximing

AU - Shen, Shuwei

AU - Liu, Guangli

AU - Yuan, Li

AU - Meng, Yuquan

AU - Lv, Xiang

AU - Shao, Pengfei

AU - Dong, Erbao

AU - Xu, Ronald X.

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

PY - 2016

Y1 - 2016

N2 - Clinical utility of many biomedical optical devices is limited by the lack of effective and traceable calibration methods. Optical phantoms that simulate biological tissues used for optical device calibration have been explored. However, these phantoms can hardly simulate both structural and optical properties of multi-layered biological tissue. To address this limitation, we develop a 3D printing production line that integrates spin coating, light-cured 3D printing and Fused Deposition Modeling (FDM) for freeform fabrication of optical phantoms with mechanical and optical heterogeneities. With the gel wax Polydimethylsiloxane (PDMS), and colorless light-curable ink as matrix materials, titanium dioxide (TiO2) powder as the scattering ingredient, graphite powder and black carbon as the absorption ingredient, a multilayer phantom with high-precision is fabricated. The absorption and scattering coefficients of each layer are measured by a double integrating sphere system. The results demonstrate that the system has the potential to fabricate reliable tissue-simulating phantoms to calibrate optical imaging devices. © 2016 SPIE.

AB - Clinical utility of many biomedical optical devices is limited by the lack of effective and traceable calibration methods. Optical phantoms that simulate biological tissues used for optical device calibration have been explored. However, these phantoms can hardly simulate both structural and optical properties of multi-layered biological tissue. To address this limitation, we develop a 3D printing production line that integrates spin coating, light-cured 3D printing and Fused Deposition Modeling (FDM) for freeform fabrication of optical phantoms with mechanical and optical heterogeneities. With the gel wax Polydimethylsiloxane (PDMS), and colorless light-curable ink as matrix materials, titanium dioxide (TiO2) powder as the scattering ingredient, graphite powder and black carbon as the absorption ingredient, a multilayer phantom with high-precision is fabricated. The absorption and scattering coefficients of each layer are measured by a double integrating sphere system. The results demonstrate that the system has the potential to fabricate reliable tissue-simulating phantoms to calibrate optical imaging devices. © 2016 SPIE.

KW - absorption

KW - FDM

KW - light-cured 3D printing

KW - scattering.

KW - spin coating

KW - tissue optical phantom

UR - https://www.scopus.com/pages/publications/85011278990

UR - https://www.scopus.com/pages/publications/85011278990#tab=impact

U2 - 10.1117/12.2246273

DO - 10.1117/12.2246273

M3 - RGC 32 - Refereed conference paper (with host publication)

SN - 9781510604674

VL - 10024

T3 - Proceedings of SPIE - The International Society for Optical Engineering

BT - Optics in Health Care and Biomedical Optics VII

PB - SPIE - International Society for Optical Engineering

T2 - Optics in Health Care and Biomedical Optics VII

Y2 - 12 October 2016 through 14 October 2016

ER -

Zhao Z, Zhou X, Shen S, Liu G, Yuan L, Meng Y et al. 3D printing of tissue-simulating phantoms for calibration of biomedical optical devices. In Optics in Health Care and Biomedical Optics VII. Vol. 10024. SPIE - International Society for Optical Engineering. 2016. 100240N. (Proceedings of SPIE - The International Society for Optical Engineering). doi: 10.1117/12.2246273

3D printing of tissue-simulating phantoms for calibration of biomedical optical devices

Abstract

Publication series

Conference

Bibliographical note

UN SDGs

Research Keywords

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