3D Printing of Individualized Microfluidic Chips with DLP-Based Printer

Jingjiang Qiu; Junfu Li; Zhongwei Guo; Yudong Zhang; Bangbang Nie; Guochen Qi; Xiang Zhang; Jiong Zhang; Ronghan Wei

doi:10.3390/ma16216984

3D Printing of Individualized Microfluidic Chips with DLP-Based Printer

Jingjiang Qiu^*, Junfu Li, Zhongwei Guo, Yudong Zhang, Bangbang Nie, Guochen Qi, Xiang Zhang, Jiong Zhang, Ronghan Wei^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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Abstract

Microfluidic chips have shown their potential for applications in fields such as chemistry and biology, and 3D printing is increasingly utilized as the fabrication method for microfluidic chips. To address key issues such as the long printing time for conventional 3D printing of a single chip and the demand for rapid response in individualized microfluidic chip customization, we have optimized the use of DLP (digital light processing) technology, which offers faster printing speeds due to its surface exposure method. In this study, we specifically focused on developing a fast-manufacturing process for directly printing microfluidic chips, addressing the high cost of traditional microfabrication processes and the lengthy production times associated with other 3D printing methods for microfluidic chips. Based on the designed three-dimensional chip model, we utilized a DLP-based printer to directly print two-dimensional and three-dimensional microfluidic chips with photosensitive resin. To overcome the challenge of clogging in printing microchannels, we proposed a printing method that combined an open-channel design with transparent adhesive tape sealing. This method enables the rapid printing of microfluidic chips with complex and intricate microstructures. This research provides a crucial foundation for the development of microfluidic chips in biomedical research.

© 2023 by the authors. Licensee MDPI, Basel, Switzerland.

Original language	English
Article number	6984
Journal	Materials
Volume	16
Issue number	21
Online published	31 Oct 2023
DOIs	https://doi.org/10.3390/ma16216984
Publication status	Published - Nov 2023

Funding

This research was funded by the National Natural Science Foundation of China (Grant No. 52171193), the High-level Foreign Expert Introduction Plan of Henan Province (Grant No. HNGD2023001), Henan Postdoctoral Science Foundation (Grant No. 201901011), Chunhui Plan of Ministry of Education of China (Grant No. HZKY20220283), Key R&D Projects of Henan Province (Grant No. 231111312400), and the Open Foundation of the State Laboratory of Fluid Power and Mechatronic Systems (Grant No. GZKF-202014).

Research Keywords

3D printing
direct printing
DLP
microfluidic chips
open channel design

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This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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AB - Microfluidic chips have shown their potential for applications in fields such as chemistry and biology, and 3D printing is increasingly utilized as the fabrication method for microfluidic chips. To address key issues such as the long printing time for conventional 3D printing of a single chip and the demand for rapid response in individualized microfluidic chip customization, we have optimized the use of DLP (digital light processing) technology, which offers faster printing speeds due to its surface exposure method. In this study, we specifically focused on developing a fast-manufacturing process for directly printing microfluidic chips, addressing the high cost of traditional microfabrication processes and the lengthy production times associated with other 3D printing methods for microfluidic chips. Based on the designed three-dimensional chip model, we utilized a DLP-based printer to directly print two-dimensional and three-dimensional microfluidic chips with photosensitive resin. To overcome the challenge of clogging in printing microchannels, we proposed a printing method that combined an open-channel design with transparent adhesive tape sealing. This method enables the rapid printing of microfluidic chips with complex and intricate microstructures. This research provides a crucial foundation for the development of microfluidic chips in biomedical research.© 2023 by the authors. Licensee MDPI, Basel, Switzerland.

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3D Printing of Individualized Microfluidic Chips with DLP-Based Printer

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