3D-printed microneedles with open groove channels for liquid extraction

Fang Leng; Mengjia Zheng; Chenjie Xu

doi:10.1002/EXP.20210109

3D-printed microneedles with open groove channels for liquid extraction

Fang Leng, Mengjia Zheng, Chenjie Xu^*

^*Corresponding author for this work

Department of Biomedical Engineering

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

35 Citations (Scopus)

40 Downloads (CityUHK Scholars)

Abstract

Microneedles (MNs) offer a simple and minimally invasive way to sample skin interstitial fluid for bioanalysis. Through the integration with portable or wearable sensing devices, it allows us to get qualitative information about some biomarkers in situ. This work is to show aMN platform with open groove channels that are manufactured using photopolymerization 3D printing. The grooves on the needle surface permit that liquid flows from the tips to the base under the influence of capillary force. The ultimate MN device can penetrate skin and tissues and sample liquid in the skin model. By taking the glucose as the model biomarker, we demonstrate that the biomarkers in the extracted liquid can be analyzed in situ by the commercial test strips attached to the back.

© 2021 The Authors. Exploration published by Henan University and John Wiley & Sons Australia, Ltd

Original language	English
Article number	20210109
Number of pages	6
Journal	Exploration
Volume	1
Issue number	3
Online published	28 Dec 2021
DOIs	https://doi.org/10.1002/EXP.20210109
Publication status	Published - Dec 2021

Funding

C.X. acknowledges the funding support from the City University of Hong Kong (#9610472), General Research Fund (GRF) from the University Grant Committee of Hong Kong (UGC) Research Grant Council (RGC) (#9042951 and #9043133), and NSFC/RGC Joint Research Scheme (#N_CityU118/20). We also appreciate the assistance of Mr. Chi Chiu LEUNG (Department of Biomedical Engineering, City University of Hong Kong) for the use of MJ Stratasys Objet 260 Connex3 3D printer.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 9 Industry, Innovation, and Infrastructure

Research Keywords

3D printing
glucose sensing
liquid extraction
microneedle

Publisher's Copyright Statement

This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/

RGC Funding Information

RGC-funded

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10.1002/EXP.20210109

252277052.pdfFinal Published version, 913 KBLicence: CC BY

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Cite this

@article{1532b5f76d73465592faebeb2593687a,

title = "3D-printed microneedles with open groove channels for liquid extraction",

abstract = "Microneedles (MNs) offer a simple and minimally invasive way to sample skin interstitial fluid for bioanalysis. Through the integration with portable or wearable sensing devices, it allows us to get qualitative information about some biomarkers in situ. This work is to show aMN platform with open groove channels that are manufactured using photopolymerization 3D printing. The grooves on the needle surface permit that liquid flows from the tips to the base under the influence of capillary force. The ultimate MN device can penetrate skin and tissues and sample liquid in the skin model. By taking the glucose as the model biomarker, we demonstrate that the biomarkers in the extracted liquid can be analyzed in situ by the commercial test strips attached to the back.{\textcopyright} 2021 The Authors. Exploration published by Henan University and John Wiley & Sons Australia, Ltd",

keywords = "3D printing, glucose sensing, liquid extraction, microneedle",

author = "Fang Leng and Mengjia Zheng and Chenjie Xu",

year = "2021",

month = dec,

doi = "10.1002/EXP.20210109",

language = "English",

volume = "1",

number = "3",

}

TY - JOUR

T1 - 3D-printed microneedles with open groove channels for liquid extraction

AU - Leng, Fang

AU - Zheng, Mengjia

AU - Xu, Chenjie

PY - 2021/12

Y1 - 2021/12

N2 - Microneedles (MNs) offer a simple and minimally invasive way to sample skin interstitial fluid for bioanalysis. Through the integration with portable or wearable sensing devices, it allows us to get qualitative information about some biomarkers in situ. This work is to show aMN platform with open groove channels that are manufactured using photopolymerization 3D printing. The grooves on the needle surface permit that liquid flows from the tips to the base under the influence of capillary force. The ultimate MN device can penetrate skin and tissues and sample liquid in the skin model. By taking the glucose as the model biomarker, we demonstrate that the biomarkers in the extracted liquid can be analyzed in situ by the commercial test strips attached to the back.© 2021 The Authors. Exploration published by Henan University and John Wiley & Sons Australia, Ltd

AB - Microneedles (MNs) offer a simple and minimally invasive way to sample skin interstitial fluid for bioanalysis. Through the integration with portable or wearable sensing devices, it allows us to get qualitative information about some biomarkers in situ. This work is to show aMN platform with open groove channels that are manufactured using photopolymerization 3D printing. The grooves on the needle surface permit that liquid flows from the tips to the base under the influence of capillary force. The ultimate MN device can penetrate skin and tissues and sample liquid in the skin model. By taking the glucose as the model biomarker, we demonstrate that the biomarkers in the extracted liquid can be analyzed in situ by the commercial test strips attached to the back.© 2021 The Authors. Exploration published by Henan University and John Wiley & Sons Australia, Ltd

KW - 3D printing

KW - glucose sensing

KW - liquid extraction

KW - microneedle

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:001274798300010

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85133902386&origin=recordpage

UR - http://www.scopus.com/inward/record.url?scp=85133902386&partnerID=8YFLogxK

U2 - 10.1002/EXP.20210109

DO - 10.1002/EXP.20210109

M3 - RGC 21 - Publication in refereed journal

C2 - 37323692

SN - 2766-8509

VL - 1

JO - Exploration

JF - Exploration

IS - 3

M1 - 20210109

ER -

3D-printed microneedles with open groove channels for liquid extraction

Abstract

Funding

UN SDGs

Research Keywords

Publisher's Copyright Statement

RGC Funding Information

Access Output

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Other Files and Links

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GRF: Development of Framework Nucleic Acid based platform technology for intradermal and transdermal delivery of oligonucleotides therapeutics

GRF: Development of Highly Swellable Microneedle Skin Patches for Skin Interstitial Fluid Sampling and In Situ Transdermal Biosensing

NSFC: Nanometallic Conductive Composite-hydrogel Core-shell Microneedle Skin Patch for Real-time Monitoring Physiological Signals

Cite this

3D-printed microneedles with open groove channels for liquid extraction

Abstract

Funding

UN SDGs

Research Keywords

Publisher's Copyright Statement

RGC Funding Information

Access Output

Other Access Options

Permanent Link

Other Files and Links

Fingerprint

Projects

GRF: Development of Framework Nucleic Acid based platform technology for intradermal and transdermal delivery of oligonucleotides therapeutics

GRF: Development of Highly Swellable Microneedle Skin Patches for Skin Interstitial Fluid Sampling and In Situ Transdermal Biosensing

NSFC: Nanometallic Conductive Composite-hydrogel Core-shell Microneedle Skin Patch for Real-time Monitoring Physiological Signals

Cite this