3D cell manipulation with honeycomb-patterned scaffold for regeneration of bone-like tissues

Zhijie Huan; Henry K. Chu; Jie Yang; Dong Sun

doi:10.1109/ICInfA.2015.7279556

3D cell manipulation with honeycomb-patterned scaffold for regeneration of bone-like tissues

Zhijie Huan^*, Henry K. Chu, Jie Yang, Dong Sun^*

^*Corresponding author for this work

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

6 Citations (Scopus)

Abstract

Dielectrophoresis (DEP) has widely been used for manipulation and patterning of biological cells. In this paper, a novel multi-layer scaffold structure was designed for patterning cells in 3D via dielectrophoresis. Honeycomb patterns were integrated in each layer of the structure in order to pattern cells into bone-like tissues. When a voltage was supplied to the scaffold structure, non-uniform electric fields were established to manipulate cells automatically, forming honeycomb-shaped patterns at different layers. To confirm the proposed cell manipulation mechanism, the electric fields were simulated and the structure was examined through experiments. Different voltage inputs were tested and a voltage input of 20V can form a uniform and complete hexagon patterns. The results show that this novel 3D scaffold is able to manipulate biological cells in 3D via dielectrophoresis rapidly.

Original language	English
Title of host publication	Proceeding of the 2015 IEEE International Conference on Information and Automation
Publisher	IEEE
Pages	1680-1685
ISBN (Print)	9781467391047
DOIs	https://doi.org/10.1109/ICInfA.2015.7279556
Publication status	Published - 28 Sept 2015
Event	The 2015 IEEE International Conference on Information and Automation - , China Duration: 8 Aug 2015 → 10 Aug 2015

Conference

Conference	The 2015 IEEE International Conference on Information and Automation
Place	China
Period	8/08/15 → 10/08/15

Research Keywords

Bones
Computer architecture
Dielectrophoresis
Electric fields
Force
Microprocessors
Three-dimensional displays

Access Output

10.1109/ICInfA.2015.7279556

Other Access Options

Check CityUHK Library

Permanent Link

Right click to copy link

Cite this

@inproceedings{51013e29b7cd46f3b3ddac16afd62c36,

title = "3D cell manipulation with honeycomb-patterned scaffold for regeneration of bone-like tissues",

abstract = "Dielectrophoresis (DEP) has widely been used for manipulation and patterning of biological cells. In this paper, a novel multi-layer scaffold structure was designed for patterning cells in 3D via dielectrophoresis. Honeycomb patterns were integrated in each layer of the structure in order to pattern cells into bone-like tissues. When a voltage was supplied to the scaffold structure, non-uniform electric fields were established to manipulate cells automatically, forming honeycomb-shaped patterns at different layers. To confirm the proposed cell manipulation mechanism, the electric fields were simulated and the structure was examined through experiments. Different voltage inputs were tested and a voltage input of 20V can form a uniform and complete hexagon patterns. The results show that this novel 3D scaffold is able to manipulate biological cells in 3D via dielectrophoresis rapidly.",

keywords = "Bones, Computer architecture, Dielectrophoresis, Electric fields, Force, Microprocessors, Three-dimensional displays",

author = "Zhijie Huan and Chu, {Henry K.} and Jie Yang and Dong Sun",

year = "2015",

month = sep,

day = "28",

doi = "10.1109/ICInfA.2015.7279556",

language = "English",

isbn = "9781467391047",

pages = "1680--1685",

booktitle = "Proceeding of the 2015 IEEE International Conference on Information and Automation",

publisher = "IEEE",

address = "United States",

note = "The 2015 IEEE International Conference on Information and Automation ; Conference date: 08-08-2015 Through 10-08-2015",

}

Huan, Z, Chu, HK, Yang, J & Sun, D 2015, 3D cell manipulation with honeycomb-patterned scaffold for regeneration of bone-like tissues. in Proceeding of the 2015 IEEE International Conference on Information and Automation., 7279556, IEEE, pp. 1680-1685, The 2015 IEEE International Conference on Information and Automation, China, 8/08/15. https://doi.org/10.1109/ICInfA.2015.7279556

3D cell manipulation with honeycomb-patterned scaffold for regeneration of bone-like tissues. / Huan, Zhijie; Chu, Henry K.; Yang, Jie et al.
Proceeding of the 2015 IEEE International Conference on Information and Automation. IEEE, 2015. p. 1680-1685 7279556.

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

TY - GEN

T1 - 3D cell manipulation with honeycomb-patterned scaffold for regeneration of bone-like tissues

AU - Huan, Zhijie

AU - Chu, Henry K.

AU - Yang, Jie

AU - Sun, Dong

PY - 2015/9/28

Y1 - 2015/9/28

N2 - Dielectrophoresis (DEP) has widely been used for manipulation and patterning of biological cells. In this paper, a novel multi-layer scaffold structure was designed for patterning cells in 3D via dielectrophoresis. Honeycomb patterns were integrated in each layer of the structure in order to pattern cells into bone-like tissues. When a voltage was supplied to the scaffold structure, non-uniform electric fields were established to manipulate cells automatically, forming honeycomb-shaped patterns at different layers. To confirm the proposed cell manipulation mechanism, the electric fields were simulated and the structure was examined through experiments. Different voltage inputs were tested and a voltage input of 20V can form a uniform and complete hexagon patterns. The results show that this novel 3D scaffold is able to manipulate biological cells in 3D via dielectrophoresis rapidly.

AB - Dielectrophoresis (DEP) has widely been used for manipulation and patterning of biological cells. In this paper, a novel multi-layer scaffold structure was designed for patterning cells in 3D via dielectrophoresis. Honeycomb patterns were integrated in each layer of the structure in order to pattern cells into bone-like tissues. When a voltage was supplied to the scaffold structure, non-uniform electric fields were established to manipulate cells automatically, forming honeycomb-shaped patterns at different layers. To confirm the proposed cell manipulation mechanism, the electric fields were simulated and the structure was examined through experiments. Different voltage inputs were tested and a voltage input of 20V can form a uniform and complete hexagon patterns. The results show that this novel 3D scaffold is able to manipulate biological cells in 3D via dielectrophoresis rapidly.

KW - Bones

KW - Computer architecture

KW - Dielectrophoresis

KW - Electric fields

KW - Force

KW - Microprocessors

KW - Three-dimensional displays

UR - http://www.scopus.com/inward/record.url?scp=84959929256&partnerID=8YFLogxK

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-84959929256&origin=recordpage

U2 - 10.1109/ICInfA.2015.7279556

DO - 10.1109/ICInfA.2015.7279556

M3 - RGC 32 - Refereed conference paper (with host publication)

SN - 9781467391047

SP - 1680

EP - 1685

BT - Proceeding of the 2015 IEEE International Conference on Information and Automation

PB - IEEE

T2 - The 2015 IEEE International Conference on Information and Automation

Y2 - 8 August 2015 through 10 August 2015

ER -

3D cell manipulation with honeycomb-patterned scaffold for regeneration of bone-like tissues

Abstract

Conference

Research Keywords

Access Output

Other Access Options

Permanent Link

Other Files and Links

Fingerprint

Cite this