高共轭性的四苯基卟啉-Ru(Ⅱ) 联吡啶配合物的合成、光学性质及光动力抗癌活性

Two amphiphilic porphyrin - ruthenium (II) complexes PorRu and PorZn ⁃ Ru were synthesized by the coordination of metal Ru(II) and porphyrin-phenanthroline ligand L which is modified with conjugated pyrazine ring at the β position of porphyrin. Two compounds were characterized and evaluated by NMR and mass spectrometry, linear and nonlinear spectral analysis, and photodynamic anti-cancer activity study. Experimental results show that the two compounds had very high ¹O₂ quantum yields (0.93, 0.82), high two-photon absorption cross-sections (619, 621 GM), and up to about 22 nmol per 10⁶ cell uptakes of nasopharyngeal carcinoma HK-1 cell line. Although no obvious sub - cellular target was observed by the co - staining cell images, the high ¹O₂ yields and good cellular uptakes still made the ruthenium compounds have good photodynamic anticancer activity against HK-1 cells. At the light dose of 2 J·cm^-2 and the administration concentration of 4 µmol·L^-1, the inhibition efficiency reached (87.44± 2.21) % and (45.03±2.85) % respectively. © 2022 Chinese Chemical Society. All rights reserved.