Abstract
AIM To study the effect of triterpenoids isolated from Ganoderma lucidum (Leyss. ex Fr.) Karst on three models of experimental liver injury in mice. METHODS The experimental models of liver injury were induced by carbon tetrachloride (CCl4), D-galactosamine (D-Gal) and Bacillus Calmette-Guerin (BCG) plus lipopolysaccharides(LPS) in mice. The serum ALT and liver TG were measured by colorimetric and Fletcher methods. The histopathologic change of the liver was assayed in mice. RESULTS GT(80 mg·kg-1) and GT2 (10, 20, 40 mg·kg-1), as malotilate, were shown to significantly inhibit the increase of serum ALT and liver triglyceride levels induced by CCl4, D-Gal or BCG plus LPS and improve the histopathologic change of liver injury in different degrees. CONCLUSION The triterpenoids isolated from Ganoderma lucidum (Leyss. ex Fr.) Karst showed powerful protective effect against liver damage induced by CCl4, D-gal and BCG plus LPS.
| Translated title of the contribution | Effects of triterpenoids from Ganoderma Lucidum (Leyss. ex Fr.) Karst on three different experimental liver injury models in mice |
|---|---|
| Original language | Chinese (Simplified) |
| Pages (from-to) | 326-329 |
| Journal | 药学学报 |
| Volume | 35 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 2000 |
| Externally published | Yes |
Research Keywords
- 灵芝
- 三萜
- 肝损伤
- 马洛替酯
- Ganoderma lucidum (Leyss. ex Fr.) Karst
- Triterpenoids
- Liver injury
- Malotilate
Fingerprint
Dive into the research topics of 'Effects of triterpenoids from Ganoderma Lucidum (Leyss. ex Fr.) Karst on three different experimental liver injury models in mice'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver