αvβ3-Isoform specific erbium complexes highly specific for bladder cancer imaging and photodynamic therapy

Yan Zhou; Chi-Fai Chan; Daniel W. J. Kwong; Ga-Lai Law; Steven Cobb; Wai-Kwok Wong; Ka-Leung Wong

doi:10.1039/c6cc09246b

α_vβ₃-Isoform specific erbium complexes highly specific for bladder cancer imaging and photodynamic therapy

Yan Zhou
, Chi-Fai Chan
, Daniel W. J. Kwong
, Ga-Lai Law
, Steven Cobb
, Wai-Kwok Wong
, Ka-Leung Wong

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

29 Citations (Scopus)

Abstract

We have synthesized a bifunctional erbium-porphyrin tumor imaging and PDT agent (Er-R₃) that is capable of killing bladder cancer cells via its selective binding to the integrin α_vβ₃ isoform overexpressed on the cell membrane. © The Royal Society of Chemistry.

Original language	English
Pages (from-to)	557-560
Journal	Chemical Communications
Volume	53
Issue number	3
DOIs	https://doi.org/10.1039/c6cc09246b
Publication status	Published - 2017
Externally published	Yes

Bibliographical note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Funding

This work was supported by the Hong Kong Baptist University (HKBU) Faculty Research Grants (FRG2/14-15/013), the Hong Kong Polytechnic University (HKPolyU), the Hong Kong Research Grants Council (HKBU 22301615, Polyu 253002/14P and Polyu 5096/13P) and the HKBU-HKPolyU Joint Research Programme (RC-ICRS/15-16/02F-KLW and RC-ICRS/15-16/02D-DWJK).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Publisher's Copyright Statement

This full text is made available under CC-BY-NC 3.0. https://creativecommons.org/licenses/by-nc/3.0/

RGC Funding Information

RGC-funded

Access Output

10.1039/c6cc09246b

422766765.pdfFinal Published version, 1.79 MBLicence: CC BY-NC

Other Access Options

Check CityUHK Library

Permanent Link

Right click to copy link

Cite this

@article{cc01c1cdb6994eafa9cbdb40e5350fac,

title = "αvβ3-Isoform specific erbium complexes highly specific for bladder cancer imaging and photodynamic therapy",

abstract = "We have synthesized a bifunctional erbium-porphyrin tumor imaging and PDT agent (Er-R3) that is capable of killing bladder cancer cells via its selective binding to the integrin αvβ3 isoform overexpressed on the cell membrane. {\textcopyright} The Royal Society of Chemistry.",

author = "Yan Zhou and Chi-Fai Chan and Kwong, \{Daniel W. J.\} and Ga-Lai Law and Steven Cobb and Wai-Kwok Wong and Ka-Leung Wong",

note = "Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].",

year = "2017",

doi = "10.1039/c6cc09246b",

language = "English",

volume = "53",

pages = "557--560",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "3",

}

TY - JOUR

T1 - αvβ3-Isoform specific erbium complexes highly specific for bladder cancer imaging and photodynamic therapy

AU - Zhou, Yan

AU - Chan, Chi-Fai

AU - Kwong, Daniel W. J.

AU - Law, Ga-Lai

AU - Cobb, Steven

AU - Wong, Wai-Kwok

AU - Wong, Ka-Leung

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

PY - 2017

Y1 - 2017

N2 - We have synthesized a bifunctional erbium-porphyrin tumor imaging and PDT agent (Er-R3) that is capable of killing bladder cancer cells via its selective binding to the integrin αvβ3 isoform overexpressed on the cell membrane. © The Royal Society of Chemistry.

AB - We have synthesized a bifunctional erbium-porphyrin tumor imaging and PDT agent (Er-R3) that is capable of killing bladder cancer cells via its selective binding to the integrin αvβ3 isoform overexpressed on the cell membrane. © The Royal Society of Chemistry.

UR - https://www.scopus.com/pages/publications/85008674682

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85008674682&origin=recordpage

U2 - 10.1039/c6cc09246b

DO - 10.1039/c6cc09246b

M3 - RGC 21 - Publication in refereed journal

C2 - 27973635

SN - 1359-7345

VL - 53

SP - 557

EP - 560

JO - Chemical Communications

JF - Chemical Communications

IS - 3

ER -