Therapeutic Potential of a Novel Deep Brain Stimulation Target Site And Neural Prosthetic Device For Treating Parkinson’s Disease

Project: Research

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Parkinson’s disease (PD) occurs commonly in elderly. “Open-loop” nature of deep brain stimulation (DBS) produces continuous and excessive stimulation to patients. Conventional DBS sites in subthalamic nucleus or globus pallidus pars interna (GPi) modulates either direct or indirect pathway of thalamo-cortical-striatal loop. Imbalance between direct and indirect pathways results in abnormal neuronal firing pattern from output nuclei affecting motor cortex, leading to undesirable side effects. Putamen is a motor integrating centre by modulating both direct and indirect pathways. Abnormal local field potential (LFP)-beta power and neuronal firing pattern detected in putamen of PD patients is associated with motor dysfunction. To explore putamen as a novel target site for PD-DBS, we demonstrated putamen-DBS is more effective than GPi-DBS in improving PD symptoms in mice. Current proposal will characterize LFP-beta power of putamen by multi-electrode array neurosipke recording, and optimize therapeutic stimulation parameters of DBS by neurobehavioral tests and electrophysiology in two mouse models of PD. In collaboration with a US-based company, optimized DBS parameters will be used to develop closed-loop putamen-DBS microchip prototype using abnormal LFP as stimulation trigger for feedback signal. Recently, we have used field-programmable gate array board to develop prototype successfully for delivering closed-loop DBS to deep cerebellar nuclei online.


Project number9440221
Grant typeITF
Effective start/end date1/07/20 → …