The Effect of the Combination of Interleukin-1β (IL-1β) and Interferon-α (IFNα) in Limiting Japanese Encephalitis virus (JEV) Replication - RMGS

Project: Research

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Description

Japanese encephalitis virus (JEV) is a zoonotic pathogen that cycles between mosquitoes, birds, pigs, and humans. Japanese encephalitis (JE) caused by JEV is a common viral encephalitis in humans and animals. However, despite significant mitigation of JE due to vaccination programs, JE continues to be a major disease burden in the Asian region. Unfortunately, no treatment has been proven to be effective for JE in clinical trials, and the widely used IFN-based therapy has little effect on inhibiting JEV infection due to its ability to evade host antiviral interferon response. Therefore, in this study, we aim to investigate whether IL-1β is a potential candidate for compensating the IFN-mediated antiviral effect against JEV in both in vitro and in vivo using mouse models. The results obtained from this study would help design a novel antiviral regimen that effectively controls immune-evasive JEV infections.

Detail(s)

Project number9229143
Grant typeDON_RMG
StatusActive
Effective start/end date1/08/23 → …