Surface Functionalization of Vertically Aligned SiNW Array for Controlled Conditioning of Stem Cells

Project: Research

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Description

Great effort has been devoted to investigating means of reducing the incidence of bone implant failures which is mainly caused by insufficient bonding between an orthopedic implant and juxtaposed bone. Insufficient bonding could be linked to poor material surface and/or mechanical properties. Developments of nanotechnology in the past few years have demonstrated that nanomaterial based scaffolds may improve contact guidance and tissue growth around the implant, and reduce friction and therefore wear for joint applications. A widely accepted strategy for improving bone tissue engineering is targeting osteoprogenitor cells in order to stimulate their osteogenic differentiation and bone forming properties. Mesenchymal stem cells have been considered the progenitor cells for the skeletal tissues. Previous reports demonstrate that the use of nanoscale disorder to stimulate MSCs to produce bone mineral in vitro, in the absence of osteogenic supplements. Silicon nanowires (SiNWs) are excellent candidates for bone tissue engineering scaffolds due to their exceptional mechanical properties. In this project, we hypothesize that we can direct growth and osteoblastic differentiation of MSCs using SiNW-based substrates through rational design and surface engineering. We will investigate the feasibility of vertically aligned SiNW-based scaffolds with different patterns serving for osteoblasts proliferation and bone formation.

Detail(s)

Project number9440072
Grant typeITF
StatusFinished
Effective start/end date1/03/1031/08/11